Kathleen G. Smith

Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

Yu-Wei Chen, Nicholas W. Plummer, Grace K. Jones, Esteban A. Oyarzabal et autres

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Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network

Yen‐Yu Ian Shih, Tzu-Hao Harry Chao, Weiting Zhang, Jingheng Zhou et autres

The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of …

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A knock‐in allele of Hand2 expressing Dre recombinase

Nicholas W. Plummer, Kathleen G. Smith, Patricia Jensen

Summary HAND2 is a basic helix–loop–helix transcription factor with diverse functions during development. To facilitate the investigation of genetic and functional diversity among Hand2‐expressing cells in the mouse, we have generated Hand2Dre, a knock‐in allele expressing Dre recombinase. To avoid disrupting Hand2 …

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Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1

Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino et autres

Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior is unknown. In addition, new animal models are required …

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Partial or complete loss of norepinephrine differentially alters contextual fear and catecholamine release dynamics in hippocampal CA1

Leslie R. Wilson, Nicholas W. Plummer, Irina Y. Evsyukova, Daniela Patino et autres

ABSTRACT Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior is unknown. In addition, new animal models are required …

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Natural locus coeruleus dynamics during feeding

Natale R. Sciolino, Madeline Hsiang, Christopher M. Mazzone, Leslie R. Wilson et autres

Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was suppressed during food consumption, …

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Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network

Esteban A. Oyarzabal, Li‐Ming Hsu, Manasmita Das, Tzu-Hao Harry Chao et autres

The default mode network (DMN) of the brain is functionally associated with a wide range of behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber photometry to investigate the selective neuromodulatory effect of …

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Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

Esteban A. Oyarzabal, Li‐Ming Hsu, Manasmita Das, Tzu-Hao Harry Chao et autres

Abstract The default mode network (DMN) of the brain is involved in cognition, emotion regulation, impulsivity, and balancing between internally and externally focused states. DMN dysregulation has been implicated in several neurological and neuropsychiatric disorders. In this study, we used functional magnetic …

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Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice

Zhenglin Gu, Kathleen G. Smith, Georgia M. Alexander, Inês C. Guerreiro et autres

Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM), also regulate …

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Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

Rachel P. Tillage, Natale R. Sciolino, Nicholas W. Plummer, Daniel J. Lustberg et autres

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A Role for the Locus Coeruleus in the Modulation of Feeding

Natale R. Sciolino, Madeline Hsiang, Christopher M. Mazzone, Leslie R. Wilson et autres

Abstract Recent data suggest that LC-NE neurons play a role in fear-induced suppression of feeding, but their endogenous activity in naturally behaving animals has not been explored. We found that endogenous activity of LC-NE neurons was enhanced during food approach and suppressed …

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Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

Rachel P. Tillage, Natale R. Sciolino, Nicholas W. Plummer, Daniel J. Lustberg et autres

ABSTRACT Accumulating evidence indicates that disruption of galanin signaling is associated with neuropsychiatric disease, but the precise functions of this neuropeptide remain largely unresolved due to lack of tools for experimentally disrupting its transmission in a cell type-specific manner. To examine the …

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