Daniel J. Lustberg

Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice

Joyce F. Liu, Daniel J. Lustberg, Abigail Galvez, Larry Cameron Liles et autres

In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE) and dopamine (DA) modulate anxiety and predator odor responses, and we have …

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Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice

Joyce F. Liu, Daniel J. Lustberg, Abigail Galvez, Larry Cameron Liles et autres

Abstract In rodents, exposure to predator odors such as cat urine acts as a severe stressor that engages innate defensive behaviors critical for survival in the wild. The neurotransmitters norepinephrine (NE) and dopamine (DA) modulate anxiety and predator odor responses, and we …

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RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus

Nicholas H. Harbin, Daniel J. Lustberg, Cheyenne D. Hurst, Jean‐François Paré et autres

RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines to restrain postsynaptic signaling and …

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Mechanisms of mGluR ‐dependent plasticity in hippocampal area CA2

Mahsa Samadi, Claire A. Hales, Daniel J. Lustberg, Shannon Farris et autres

Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the other CA subregions. Notably, this includes a lack of typical long-term potentiation of stratum radiatum synapses. CA2 neurons express high levels of several known and potential regulators of …

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RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus

Nicholas H. Harbin, Daniel J. Lustberg, Cheyenne D. Hurst, Jean‐François Paré et autres

RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. There, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines to restrain postsynaptic signaling and plasticity. Previous …

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The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda et autres

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the emergence …

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The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda et autres

Abstract The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and alpha-synuclein pathology in Alzheimer’s disease (AD) and Parkinson’s disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the …

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Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Daniel J. Lustberg, Joyce Q. Liu, Alexa F. Iannitelli, Samantha O. Vanderhoof et autres

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Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Daniel J. Lustberg, Joyce Q. Liu, Alexa F. Iannitelli, Samantha O. Vanderhoof et autres

Abstract Exposure to unfamiliar odorants induces an array of repetitive defensive and non-defensive behaviors in rodents which likely reflect adaptive stress responses to the uncertain valence of novel stimuli. Mice genetically deficient for dopamine β-hydroxylase ( Dbh−/− ) lack the enzyme required …

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Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome

Kelly E. Carstens, Daniel J. Lustberg, Emma K. Shaughnessy, Katharine E McCann et autres

Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the brains of people with Rett syndrome (RTT). We previously reported that PNNs function to restrict synaptic plasticity in hippocampal area CA2, which is unusually resistant to long-term potentiation (LTP) …

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RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures

Stephanie L. Foster, Daniel J. Lustberg, Nicholas H. Harbin, Sara N. Bramlett et autres

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Regulator of G‐protein signaling 14 (RGS14) alters hippocampal pathology following excitotoxic injury due to status epilepticus

Nicholas H. Harbin, Daniel J. Lustberg, David Weinshenker, John R. Hepler

Regulators of G‐protein signaling (RGS) proteins are critical for proper regulation of receptor‐mediated signaling in the central nervous system and elsewhere. One such RGS protein, RGS14, is highly expressed in pyramidal cells of area CA2 of the hippocampus and interacts with multiple …

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