Junji Fujikura

Selecting between pharmacotherapy and bariatric surgery in East Asia

Yamato Keidai, Junji Fujikura, Hiroto Minamino, Kohei Takesue et autres

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294.7: Allogeneic transplantation of human induced pluripotent stem cell-derived islet cells in a patient with type 1 diabetes.

Kei Yamane, Takayuki Anazawa, Junji Fujikura, Toshihiro Nakamura et autres

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Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Chika Saegusa, Yusuke Masano, F. Becker, Mari Nakamura et autres

. To investigate the pathophysiology of MELAS, we generated brain organoids from multiple induced pluripotent stem cell (iPSC) lines derived from a patient with MELAS carrying the m.3243A>G variant. These lines share an identical nuclear genetic background but differ in their heteroplasmy …

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Impact of Mitochondrial A3243G Mutation on Skeletal Muscle Energy Metabolism: Evidence from Human Induced Pluripotent Stem Cell-Derived Skeletal Muscle Cells

Ritsuko Oikawa, Kenichi Yokota, Junji Fujikura, Tomoya Uchimura et autres

The study of skeletal muscle disorders in patients with mitochondrial diseases is crucial for gaining insights into disease physiology; however, their molecular mechanisms have not been fully elucidated. We previously established human-induced pluripotent stem (iPS) cells in two patients with the mitochondrial …

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Application of human iPSC-derived white, beige, and brown adipocytes for metabolic disease modeling and transplantation therapy

Yamato Keidai, Junji Fujikura, Daisuke Yabe

Adipocyte dysfunction plays a critical role in the pathogenesis of metabolic diseases, including type 2 diabetes (T2D). Human induced pluripotent stem cells (hiPSCs) offer a powerful platform for generating white, beige, and brown adipocytes, supporting both disease modeling and therapeutic research. This …

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A Case of Post-transplant Lymphoproliferative Disorder After Successful Treatment of Islet Transplantation Without Graft Rejection

Koki Kurahashi, Takayuki Anazawa, Kei Yamane, Kentaro Tsuji et autres

Post-transplant lymphoproliferative disorder (PTLD) is a lymphoid or plasmacytic proliferation that occurs in association with immunosuppression and is recognized as a relatively rare but serious complication following solid organ transplantation; however, PTLD following islet transplantation is extremely rare, and its optimal management …

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Case report: Duplication of the GCK gene is a novel cause of nesidioblastosis: evidence from a case with Silver-Russell syndrome-like phenotype related to chromosome 7

Ichiro Yamauchi, Hidenori Kawasaki, Takuro Hakata, Daisuke Tanaka et autres

Silver-Russell syndrome (SRS) is a syndrome characterized by prenatal and postnatal growth retardation, facial features, and body asymmetry. SRS is often complicated with hypoglycemia, whose etiology is unclear. We describe the clinical course of 25-year-old man with hypoglycemia. We diagnosed him with …

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Toward a cure for diabetes: iPSC and ESC ‐derived islet cell transplantation trials

Junji Fujikura, Takayuki Anazawa, Tarō Toyoda, Yasuko Kimura et autres

Advancements in regenerative medicine, particularly through the use of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), are garnering substantial attention as potential solutions to the limited availability of donors, leading to prolonged waiting periods for people with type 1 …

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Human RFX6 regulates endoderm patterning at the primitive gut tube stage

Toshihiro Nakamura, Junji Fujikura, Ryo Ito, Yamato Keidai et autres

Abstract Transcriptional factor RFX6 is known to be a causal gene of Mitchell–Riley syndrome (MRS), an autosomal recessive neonatal diabetes associated with pancreatic hypoplasia and intestinal atresia/malformation. The morphological defects are limited to posterior foregut and mid-hindgut endodermal lineages and do not …

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Circularity of islets is a distinct marker for the pathological diagnosis of adult non-neoplastic hyperinsulinemic hypoglycemia using surgical specimens

Ryota Nakagawa, Sachiko Minamiguchi, Tatsuki R. Kataoka, Junji Fujikura et autres

BACKGROUND: Adult non-neoplastic hyperinsulinemic hypoglycemia (ANHH), also known as adult-onset nesidioblastosis, is a rare cause of endogenous hyperinsulinemic hypoglycemia in adults. This disease is characterized by diffuse hyperplasia of pancreatic endocrine cells and is diagnosed by a pathological examination. While diagnostic criteria …

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Circularity of islets is a distinct marker for the pathological diagnosis of adult-onset nesidioblastosis in surgical specimens

Ryota Nakagawa, Sachiko Minamiguchi, Tatsuki R. Kataoka, Junji Fujikura et autres

Abstract Background Nesidioblastosis is a rare cause of endogenous hyperinsulinemic hypoglycemia in adults (adult-onset nesidioblastosis). This disease is characterized by diffuse hyperplasia of pancreatic endocrine cells and diagnosed by a pathological examination. The diagnostic criteria of this disease have been proposed, and …

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Noninvasive evaluation of donor and native pancreases following simultaneous pancreas–kidney transplantation using positron emission tomography/computed tomography

Takaaki Murakami, Toshihiro Nakamura, Hiroyuki Fujimoto, Junji Fujikura et autres

ABSTRACT It is crucial to develop practical and noninvasive methods to assess the functional beta‐cell mass in a donor pancreas, in which monitoring and precise evaluation is challenging. A patient with type 1 diabetes underwent noninvasive imaging following simultaneous kidney–pancreas transplantation with …

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