Toshihiro Nakamura

294.7: Allogeneic transplantation of human induced pluripotent stem cell-derived islet cells in a patient with type 1 diabetes.

Kei Yamane, Takayuki Anazawa, Junji Fujikura, Toshihiro Nakamura et autres

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Decreased β-cell function in a case with Becker muscular dystrophy accompanied by post-transplant diabetes

Kazuya Motohashi, Takaaki Murakami, Daisuke Otani, Toshihiro Nakamura et autres

Summary: Duchenne and Becker muscular dystrophy (DMD/BMD) are genetic disorders characterized by progressive muscle degeneration due to alterations of the dystrophin protein. The degeneration of skeletal muscles and subsequent replacement with adipose tissue affect motor function as well as insulin sensing and …

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Unveiling immune cell response disparities in human primary cancer-associated fibroblasts between two- and three-dimensional cultures

Nikhil Nitin Kulkarni, Masashi Yamaji, Tsubasa Shiraishi, Thang Quoc Pham et autres

Cancer-associated fibroblasts (CAFs) play pivotal roles in solid tumor initiation, growth, and immune evasion. However, the optimal biomimetic modeling conditions remain elusive. In this study, we investigated the effects of 2D and 3D culturing conditions on human primary CAFs integrated into a …

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Impact of diabetes on vascular endothelial growth factor D and cardiovascular mortality in patients with suspected or known coronary artery disease: the ANOX study

Hiromichi Wada, M. Suzuki, M Matsuda, Yoichi Ajiro et autres

Abstract Background Vascular endothelial growth factor D (VEGF-D) is a secreted glycoprotein that can induce lymphangiogenesis and angiogenesis. We recently demonstrated that serum levels of VEGF-D are independently associated with all-cause mortality in patients with suspected or known coronary artery disease (CAD). …

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Abstract 15495: Serial Measurement of Vascular Endothelial Growth Factor-D in Heart Failure: The PREHOSP-CHF Study

Moritake Iguchi, Hiromichi Wada, Tsuyoshi Shinozaki, Masahiro Suzuki et autres

Background: Vascular endothelial growth factor-D (VEGF-D) is a secreted glycoprotein that can act as lymphangiogenic and angiogenic growth factors. We recently reported that VEGF-D appeared to be a prognostic marker for major adverse cardiovascular events (MACE), defined as a composite of cardiovascular …

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Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model

Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano et autres

For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved based on the mechanistic understanding of pancreatic differentiation. Here, we aimed to elucidate the molecular mechanisms underlying pancreatic endoderm differentiation by searching …

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Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

Annika Hausmann, Boas Felmy, Leo Kunz, Sanne Kroon et autres

Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this balance and how bacterial exposure elicits the process. Pure LPS induces epithelial NF-κB activation in vivo. However, we found …

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Abstract 13712: Association Between Soluble Vascular Endothelial Growth Factor Receptor-2 and Prognosis in Patients With Chronic Heart Failure: The PREHOSP-CHF Study

Moritake Iguchi, Hiromichi Wada, Tsuyoshi Shinozaki, Masahiro Suzuki et autres

Introduction: Soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) acts as an endogenous inhibitor of VEGF, a key regulator of angiogenesis and lymphoangiogenesis. However, little is known about the critical role of sVEGFR-2 in heart failure (HF). Methods: We performed a multicenter prospective …

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2060-P: RFX6, a Causative Gene of Mitchell-Riley Syndrome, Regulates ParaHox Genes in Early Endodermal Differentiation

Toshihiro Nakamura, Junji Fujikura, Ryo Ito, Nobuya Inagaki

Background: RFX6 was identified as a causative gene of Mitchell-Riley syndrome (MRS), an autosomal recessive disease associated with neonatal diabetes and morphological disorders in development of the endodermal lineage such as pancreatic hypoplasia and intestinal atresia. However, little is known of RFX6 …

CD11b + CD103 - Sentinel DCs Relay a Tunable Antibacterial NFκB Response in Intestinal Epithelial Cells Via TNF

Annika Hausmann, Boas Felmy, Leo Kunz, Giverny Ganz et autres

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Diesel engine air path control based on neural approximation of nonlinear MPC

Ryuta Moriyasu, Sayaka Nojiri, Akio Matsunaga, Toshihiro Nakamura et autres

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Ischemic Brain Injury and Regulatory T Cells

Minako Ito, Srirat Tanakorn, Toshihiro Nakamura, Kyoko Komai et autres

Inflammation and immune responses after stroke, including ischemic cerebral infarction, play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues, which subsequently regulate …