Mucosal tissue NK cells directly mediate tissue protection and repair during infection
Rattachement africain : us, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Preserving barrier integrity is of great importance in mucosal tissues while simultaneously defending against inflammatory threats and exposures to pathogens. NK cells at barrier sites are essential for viral control during infections such as herpes simplex virus 2 (HSV-2) but must also balance pathogen response with tissue protection. We have characterized human tissue NK cells in the vaginal tissue (VT) as having distinct effector and tissue protective functions. Using scRNA-seq and high-parameter flow cytometry, we uncovered a unique signature for VT NK cells, indicating a reduced effector phenotype with increased factors related to tissue residency and immunoregulation at steady state. Despite their functionally quiescent nature, these cells were able to respond robustly to inflammatory signals, suggesting they are poised for pathogen response. We found that the gene signatures between mouse and human NK cells were remarkably similar, demonstrating the feasibility of using a mouse model to probe distinct NK cell functions during mucosal infection. In mice, VT NK cells responded robustly to acute HSV-2 infection and retained an enhanced recall potential after viral clearance. They also secreted tissue repair factors and played a role in restricting tissue damage following viral infection. Our data, using both human tissues and a mouse model, reveal an unexpected role of mucosal tissue NK cells in the VT in balancing host protection with tissue repair in the context of localized mucosal tissue infection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Mucosal tissue NK cells directly mediate tissue protection and repair during infection
- Date Crossref
- 09/04/2025
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fred Hutch Cancer Center pays non établi dans la noticeOrganisation à but non lucratif
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Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa Cape Town, Afrique du Sud (code pays fourni par la source)Organisation à but non lucratif
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University of Washington Department of Global Health pays non établi dans la noticeUniversité ou école supérieure
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Vaccine and Infectious Disease Division pays non établi dans la noticeInstitution
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Comparative Pathology pays non établi dans la noticeInstitution
Fred Hutch Cancer Center, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (Cape Town, Afrique du Sud) et Department of Global Health — University of Washington, avec 2 autres affiliations. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.