Yukako Obata

Distinct weaning phenotypes in patients unsuccessful in weaning from invasive mechanical ventilation: a secondary analysis of the WEAN SAFE cohort

Reginald Caldecott, Yueyun Zhu, Bairbre A. McNicholas, Emanuele Rezoagli et autres

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Rhabdomyolysis in a Long-Term Statin User Without Traditional Risk Factors: A Case Report

Hiroyuki Naritaka, Yoshitaka Aoki, Yukako Obata, Soichiro Mimuro et autres

We report a rare case of rhabdomyolysis in a 64-year-old man who had been receiving long-term statin therapy for hyperlipidemia. The patient initially presented with symptoms of acute appendicitis, which later progressed to acute renal failure and rhabdomyolysis. No commonly identified risk …

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Postoperative norepinephrine versus dopamine in patients undergoing noncardiac surgery: a propensity-matched analysis using a nationwide intensive care database

Yoshitaka Aoki, Mikio Nakajima, Sho Sugimura, Yasuhito Suzuki et autres

BACKGROUND: Choosing catecholamines, such as norepinephrine and dopamine, for perioperative blood pressure control is essential for anesthesiologists and intensivists. However, studies specific to noncardiac surgery are limited. Therefore, we aimed to evaluate the effects of postoperative norepinephrine and dopamine on clinical outcomes …

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Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto et autres

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Systemic Seizures after Flumazenil Administration for Remimazolam

Ryoji OBATA, Etsuyo HORI, Yukako Obata

新しい静脈麻酔薬レミマゾラムは，過鎮静の場合フルマゼニルで拮抗できる調節性の良い全身麻酔薬である．今回，脳室腹腔（VP）シャント機能不全による水頭症が悪化したため，レミマゾラムで麻酔導入しデスフルランとレミフェンタニルで維持した全身麻酔手術を行った．麻酔終了時にレミマゾラムの効果残存を疑いフルマゼニルを投与した直後に，全身性痙攣を生じた症例を経験した．

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Treatment-resistant venous thrombosis and pulmonary embolism in a patient with granulomatosis with polyangiitis: a case report

Chiharu Wakuda, Yoshitaka Aoki, Sho Sugimura, Takayuki Katsuragawa et autres

BACKGROUND: We herein present a case of venous thrombosis that developed more than 20 years after diagnosis of granulomatosis with polyangiitis (GPA), although many reports of GPA have described venous thrombosis within 1 year of diagnosis. CASE PRESENTATION: A 73-year-old man with …

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A MULTI-INSTITUTIONAL COLLABORATIVE STUDY OF PRETRANSFUSION TESTS IN PATIENTS WHO RECEIVED ANTI-CD38 THERAPY

Chiaki Yamada, Akihiro Takeshita, Masaki Ri, Yuichi Hasegawa et autres

抗CD38抗体投与例に対する正確で効率的な輸血検査を検討する上で，検査の実態と問題点を把握することは重要である．抗CD38抗体投与例の輸血検査，赤血球製剤（RBC）輸血，臨床側との情報共有に関する国内多施設共同研究を実施した．

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A newly devised flow cytometric antibody binding assay helps evaluation of dithiothreitol treatment for the inactivation of CD38 on red blood cells

Hiroaki Furumaki, Akihiro Takeshita, Hitoshi Ohto, Chiaki Yamada et autres

BACKGROUND AND OBJECTIVES: Anti-CD38 monoclonal antibodies, including daratumumab and isatuximab, often interfere with pretransfusion testing. Dithiothreitol (DTT) treatment of red blood cells (RBCs) negates this interference. However, the optimum DTT concentration and treatment time have not been well defined. Here, we quantified …

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Optimum DTT Concentration and Treatment Time for CD38 Inactivation on RBCs Analyzed By a Newly-Devised Flow Cytometric Antibody Binding Assay

Hiroaki Furumaki, Akihiro Takeshita, Chiaki Yamada, Harumi Fujihara et autres

Background: Anti-CD38 monoclonal antibodies (MoAbs), including daratumumab and isatuximab, are introduced in the treatment of multiple myeloma (MM). However, CD38 is also expressed on red blood cells (RBCs), so that free anti-CD38 MoAbs in patient sera sometimes binds to test RBCs in …

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PROSPECTIVE STUDY ON THE EXPRESSION OF IRREGULAR ERYTHROCYTE ANTIBODIES AFTER TRANSFUSION-A PILOT STUDY-

Harumi Fujihara, Keiko Ishizuka, Hiroko Watanabe, Hiroaki Furumaki et autres

不規則抗体検査は，通常赤血球製剤の輸血後には実施しないため，輸血後の各不規則抗体の真の陽性率は不明である．輸血後の不規則抗体の陽性化について多施設共同前方向性研究を企画し，今回はそのパイロット試験を実施した．

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Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study

Akihiro Takeshita, Norio Asou, Yoshiko Atsuta, Toru Sakura et autres

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Bradykinin regulates plasmin-induced endothelial Ca2+ response in PARs dependent pathway

Yukako Obata, Kazuhiko Takeuchi, Akio Hakamata, Keiich Odagiri et autres

Background: Plasmin is a fibrinolytic factor and a serine protease that activates protease-activated receptors (PARs) to produce endothelium-derived relaxing factors (EDRFs) such as nitric oxide and prostacyclin. Nitric oxide and prostacyclin production is regulated, at least in part, by the intracellular Ca2+ …

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