Matthew Muller

Comparative Efficacy of Vancomycin and Fidaxomicin Regimens for the Prevention of Recurrent Clostridioides difficile Infection: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Connor Prosty, Guillaume Butler‐Laporte, James Brophy, Émilie Bortolussi‐Courval et autres

ABSTRACT Background The optimal treatment for first episodes and first recurrences of Clostridioides difficile infections (CDI) is unknown and there is emerging evidence for pulse-and-taper (P-T) regimens. Therefore, we sought to estimate the relative efficacy of treatment options. Methods MEDLINE and CENTRAL …

ca (code pays fourni par la source)

Whole blood epigenomic and transcriptomic characterization identifies vulnerable molecular subtypes of chronic coronary disease

Matthew Muller, MacIntosh Cornwell, Sandhya Rajkumar, Ze Chen et autres

Chronic coronary disease (CCD) remains a leading cause of morbidity and mortality worldwide. However, current clinical assessments, including tests of inducible ischemia or coronary artery disease severity poorly discriminate risk for future cardiovascular (CV) disease events among this population with established CCD. …

us, fi (code pays fourni par la source)

P-645. Post-pandemic changes in the epidemiology of invasive pneumococcal disease in adults in Toronto, Canada

Altynay Shigayeva, Christopher Kandel, Shiva Barati, Gloria Crowl et autres

Abstract Background Substantial reductions in invasive pneumococcal disease (IPD) occurred during the COVID-19 pandemic. Disease incidence then increased in 2022. We assessed whether the epidemiology of IPD had changed in 2022/3 when compared to that prior to the pandemic.Figure 1:Incidence of IPD …

ca, us (code pays fourni par la source)

81 mRNA COVID-19 vaccine safety among children and adolescents from the Canadian National Vaccine Safety Network

Otto G. Vanderkooi, Julie A. Bettinger, Manish Sadarangani, Karina A. Top et autres

Abstract Background The Canadian National Vaccine Safety Network (CANVAS) expanded its active safety surveillance for COVID-19 vaccines among children and adolescents during the COVID-19 pandemic. Objectives This analysis aimed to determine whether the first or second dose of mRNA COVID-19 vaccination is …

mRNA COVID-19 Vaccine Safety Among Children and Adolescents from the Canadian National Vaccine Safety Network Cohort Study

Phyumar Soe, Otto G. Vanderkooi, Manish Sadarangani, Monika Naus et autres

ca (code pays fourni par la source)

Topological Dynamics of Functional Neural Network Graphs During Reinforcement Learning

Matthew Muller, Steve Kroon, Stephan K. Chalup

au, Afrique du Sud (code pays fourni par la source)

89. On-going impact of the SARS-CoV-2 pandemic on the evolution of carbapenemase-producing Enterobacterales in Ontario, Canada

Mohammad Mozafarihashjin, Alainna Juliette Jamal, Christopher E. Kandel, Philipp P. Kohler et autres

Abstract Background The spread of carbapenemase-producing Enterobacterales (CPE) is global threat. Numerous outbreaks of CPE have been reported during the COVID-19 pandemic. We describe the impact of of the SARS-CoV-2 pandemic on the emergence of CPE in south-central Ontario, Canada. Incidence of …

ca, ch (code pays fourni par la source)

Evaluation of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and ClinPro Tools as a Rapid Tool for Typing Streptococcus pyogenes

Manal Tadros, Ana L. Cabrera, Larissa M. Matukas, Matthew Muller

Abstract Background Timely strain typing of group A Streptococci (GAS) is necessary to guide outbreak recognition and investigation. We evaluated the use of (matrix-assisted laser desorption ionization time-of-flight mass spectrometry) combined with cluster analysis software to rapidly distinguish between related and unrelated …

ca (code pays fourni par la source)

A165 INVASIVE GASTRIC MUCORMYCOSIS - CASE REPORT OF A RARE CAUSE OF UPPER GASTROINTESTINAL BLEEDING

Arif M. Yusuf, Laura N. Castellani, Xiaoling Xiong, Matthew Muller et autres

Mucormycosis is a rare but potentially life threatening fungal infection. Typically presenting as a rhino-orbital-cerebral infection in severely immunocompromised patients, it less commonly causes infection of the gastrointestinal tract. This report outlines the rare case of a patient with multiple myeloma who …

ca (code pays fourni par la source)

Characterization of a Pineal Region Malignant Rhabdoid Tumor

Matthew Muller, Sherri Lynn Hubbard, Kozo Fukuyama, Peter B. Dirks et autres

The malignant rhabdoid tumor (MRT) of the central nervous system is a highly aggressive neoplasm of early infancy which is characterized by brain invasion and widespread dissemination along cerebrospinal fluid pathways. As the process of tumor invasion is mediated in part by …

ca, gb (code pays fourni par la source)

Cognitive functions after chemotherapy

Sanne B. Schagen, Matthew Muller, Willem J. Boogerd, Sjoerd Rodenhuis et autres

Astrocytoma Adhesion to Extracellular Matrix: Functional Significance of Integrin and Focal Adhesion Kinase Expression

James T. Rutka, Matthew Muller, Sherri Lynn Hubbard, Jennifer Forsdike et autres

Evidence is accumulating implicating a role for integrins in the pathogenesis of cancer, a disease in which alterations in cellular growth, differentiation, and adhesive characteristics are defining features. In the present report we studied a panel of 8 human astrocytoma cell lines …

gb, ca (code pays fourni par la source)