Francesco Saccardo

Hepatitis B virus-infection related cryoglobulinemic vasculitis. Clinical manifestations and the effect of antiviral therapy: A review of the literature

Cesare Mazzaro, Riccardo Bomben, Marcella Visentini, Laura Gragnani et autres

Objective: Hepatitis B virus (HBV) infection causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Furthermore, about 20% of the patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV), polyarteritis nodosa, non-rheumatoid arthritis, glomerulonephritis and non-Hodgkin lymphoma. This review analyzed literature data on clinical …

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Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scirè, Antônio Carlos Marangoni et autres

Cryoglobulinemic vasculitis (CV) or mixed cryoglobulinemic syndrome (MCS) is a systemic small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes, called cryoglobulins. It is often secondary to hepatitis C virus (HCV), autoimmune diseases, and hematological malignancies. CV usually …

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Hepatitis B Virus-Related Cryoglobulinemic Vasculitis: Review of the Literature and Long-Term Follow-Up Analysis of 18 Patients Treated with Nucleos(t)ide Analogues from the Italian Study Group of Cryoglobulinemia (GISC)

Cesare Mazzaro, Luigino Dal Maso, Laura Gragnani, Marcella Visentini et autres

Hepatitis B virus (HBV) chronic infection causes progressive liver damage, although about 20% of patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV). Clinical manifestations range from mild to moderate (purpura, asthenia, arthralgia) to severe (leg ulcers, peripheral neuropathy, glomerulonephritis, non-Hodgkin lymphoma). …

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Provisional recommendations for SARS-CoV-2 vaccination in patients with cryoglobulinaemic vasculitis

Salvatore Scarpato, Marco Sebastiani, Luca Quartuccio, Piero Marson et autres

People with cryoglobulinaemic vasculitis (CV) have an increased risk of infections, attributed to different causes: impairment of the immune system due to the disease itself, comorbidities, and immunosuppressive therapy. Therefore, these patients may be at high risk for a more severe course …

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Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Caterina Vacchi, Marcella Visentini, Laura Gragnani, Paolo Fraticelli et autres

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Recommendations for managing the manifestations of severe and life-threatening mixed cryoglobulinemia syndrome

Massimo Galli, Giuseppe Monti, Piero Marson, Patrizia Scaini et autres

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THU0289 PERSISTENCE OF CIRCULATING CRYOGLOBULINS AND RELATED SYMPTOMS AFTER HEPATITIS C VIRUS ERADICATION IN PATIENTS WITH MIXED CRYOGLOBULIN SYNDROME

Cinzia Bassoli, Letizia Oreni, Salvatore Sollima, Francesco Saccardo et autres

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HCV-unrelated cryoglobulinaemic vasculitis: the results of a prospective observational study by the Italian Group for the Study of Cryoglobulinaemias (GISC).

Massimo Galli, Letizia Oreni, Francesco Saccardo, Laura Castelnovo et autres

OBJECTIVES: To investigate the clinical and laboratory patterns of HCV-unrelated cryoglobulinaemic vasculitis (CV), and the factors influencing its outcome. METHODS: Prospective study of all anti-HCV and HCV-RNA negative patients with CV who have been observed since January 2004 in 17 centres participating …

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Retreatment regimen of rituximab monotherapy given at the relapse of severe HCV-related cryoglobulinemic vasculitis: Long-term follow up data of a randomized controlled multicentre study

Luca Quartuccio, Francesca Zuliani, L. Corazza, Patrizia Scaini et autres

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OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins

Luca Quartuccio, L. Corazza, Manuel Ramos‐Casals, Soledad Retamozo et autres

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Validation of the classification criteria for cryoglobulinaemic vasculitis

Luca Quartuccio, Miriam Isola, L. Corazza, Manuel Ramos‐Casals et autres

OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV). METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard …

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OP0228 Rituximab Monotherapy of Severe Hcv-Related Cryoglobulinemic Vasculitis for More than 2 Years: Follow-Up of A Randomized Controlled Multicentre Study

Luca Quartuccio, Francesca Zuliani, L. Corazza, Patrizia Scaini et autres

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