Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
Rattachement africain : cl, ch. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Teneurins are a family of highly conserved pair-rule proteins involved in morphogenesis and development of the central nervous system. Their function in adult tissues and in disease is largely unknown. Recent evidence suggests a role for dysregulated expression of Teneurins in human tumors, but systematic investigations are missing. Here, we investigated Teneurin-2 and Teneurin-4 expression in various cancer cell lines and in ovarian tumor tissues. Teneurin-2 and Teneurin-4 were expressed in most of the breast cancer cell lines tested. Teneurin-4 was also detected in ovarian cancer cell lines, and throughout ovarian tumors and normal ovary tissue. Ovarian tumors with low Teneurin-4 expression showed less differentiated phenotypes and these patients had shorter mean overall survival. Similarly, Teneurin-2 expression correlated with overall survival as well, especially in patients with serous tumors. In the various cell lines, 5-Aza-cytidine-induced changes in DNA methylation did not alter expression of Teneurin-2 and Teneurin-4, despite the existence of predicted CpG islands in both genes. Interestingly, however, we found evidence for the control of Teneurin-2 expression by the oncogenic growth factor FGF8. Furthermore, we identified multiple transcript splicing variants for Teneurin-2 and Teneurin-4, indicating complex gene expression patterns in malignant cells. Finally, downregulation of Teneurin-4 expression using siRNA caused a cell-type dependent increase in proliferation and resistance to cisplatin. Altogether, our data suggest that low Teneurin-4 expression provides a growth advantage to cancer cells and marks an undifferentiated state characterized by increased drug resistance and clinical aggressiveness. We conclude that Teneurin-2 and Teneurin-4 expression levels could be of prognostic value in ovarian cancer.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
- Date Crossref
- 04/05/2017
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidad del Desarrollo pays non établi dans la noticeUniversité ou école supérieure
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Clínica Alemana Division of Pathology pays non établi dans la noticeÉtablissement de santé
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Pontificia Universidad Católica de Chile pays non établi dans la noticeUniversité ou école supérieure
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Advanced Center for Chronic Diseases pays non établi dans la noticeStructure de recherche
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University of Bern Institute of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Center for Genetics and Genomics pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Division of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Biological Sciences Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
Universidad del Desarrollo, Division of Pathology — Clínica Alemana et Pontificia Universidad Católica de Chile, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.