Ying R. Huang

PHLA: A pre-trained model based method incorporating HLA-peptide binding and immunogenicity

Jixiang Fan, Jianzhang Zhang, Ying R. Huang, Xiu‐Xiu Zhan et autres

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Molecular mechanisms of Larimichthys crocea's adaptation to fishmeal-free diets: Insights from liver proteomics and functional analysis of Alpha-2-HS-glycoprotein

Zhenye Zhao, Ren Peng, Ying R. Huang, G. H. Wang et autres

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Inhibition and transport mechanisms of the ABC transporter hMRP5

Ying R. Huang, Chenyang Xue, Ruiqian Bu, Cang Wu et autres

Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving multidrug resistance. To uncover the mechanism of hMRP5, we determine six distinct cryo-EM structures, revealing an autoinhibitory N-terminal peptide that must dissociate to permit subsequent substrate recruitment. Guided by these …

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Mild Iron-Catalyzed Oxidative Cross-Coupling of Quinoxalinones with Indoles

Hangcheng Ni, Hui Mao, Ying R. Huang, Yi Lu et autres

Utilizing iron chloride as a Lewis acid catalyst, we developed a straightforward and mild oxidative cross-coupling reaction between quinoxalinones and indoles, yielding a series of versatile 3-(indol-3-yl)quinoxalin-2-one derivatives. This approach allows for the incorporation of a wide array of functional groups into …

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The effect of the mitochondria-targeted antioxidant Mito-tempo during sperm ultra-rapid freezing

Chunyuan Li, Juan Liu, Qi‐Yuan Zheng, Nian Liu et autres

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Protective effect of acteoside on hydrogen peroxide-induced oxidative damage in human corneal epithelial cells

Ying R. Huang, Qianyi Peng

Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4

Ying R. Huang, Chenyang Xue, Liangdong Wang, Ruiqian Bu et autres

Human multidrug resistance protein 4 (hMRP4, also known as ABCC4), with a representative topology of the MRP subfamily, translocates various substrates across the membrane and contributes to the development of multidrug resistance. However, the underlying transport mechanism of hMRP4 remains unclear due …

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Conformational cycle of human polyamine transporter ATP13A2

Jianqiang Mu, Chenyang Xue, Lei Fu, Zongjun Yu et autres

Dysregulation of polyamine homeostasis strongly associates with human diseases. ATP13A2, which is mutated in juvenile-onset Parkinson's disease and autosomal recessive spastic paraplegia 78, is a transporter with a critical role in balancing the polyamine concentration between the lysosome and the cytosol. Here, …

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Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying R. Huang, Martin Sendzik, Jeff Zhang, Zhenting Gao et autres

Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a molecular level, PRC2 catalyzes methylation of histone H3 lysine 27 (H3K27), …

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The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta

Shawna Battle, Valentin Gogonea, Belinda B. Willard, Zeneng Wang et autres

Protein lysine carbamylation is an irreversible post-translational modification resulting in generation of homocitrulline ( N -ε-carbamyllysine), which no longer possesses a charged ε-amino moiety. Two distinct pathways can promote protein carbamylation. One results from urea decomposition, forming an equilibrium mixture of cyanate …

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Improving pea protein functionality by combining high-pressure homogenization with an ultrasound-assisted Maillard reaction

Sheliang Zhao, Ying R. Huang, David Julian McClements, Xuebo Liu et autres

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Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment

Ji Yue Zhang, Jiang-Wei Zhang, Michael Kiffe, Markus Walles et autres

MAK683 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine) is a potent and orally bioavailable EED inhibitor for the potential treatment in oncology. Pharmacokinetics (PK) in preclinical species are characterised by low to moderate plasma clearances, high oral exposure, and moderate to high oral bioavailability at the dose of …

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