Benjamin A. Siranosian

The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia

Jonas Schlüter, Ana Djuković, Bradford P. Taylor, Jinyuan Yan et autres

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Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling

Tamina Rückert, Geoffroy Andrieux, Melanie Boerries, Kathrin Hanke-Müller et autres

Acute graft-versus-host disease (aGVHD), which is driven by allogeneic T cells, has a high mortality rate and limited treatment options. Human β-defensin 2 (hBD-2) is an endogenous epithelial cell-derived host-defense peptide. In addition to its antimicrobial effects, hBD-2 has immunomodulatory functions thought …

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A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Advanced Myelofibrosis (MF): Updated Results and Genomic Analyses

Kristen Marie Pettit, Harinder Singh Gill, Abdulraheem Yacoub, Terrence Bradley et autres

The need for therapies for myelofibrosis (MF) persists, especially in the setting of JAK inhibitor failure. Lysine-specific demethylase-1 (LSD1) is a histone demethylase critical for self-renewal potential of malignant stem cells and progenitor maturation. Bomedemstat is an oral LSD1 inhibitor clinically active …

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The TaxUMAP atlas: efficient display of large clinical microbiome data reveals ecological competition involved in protection against bacteremia

Jonas Schlüter, Ana Djuković, Bradford P. Taylor, Jinyuan Yan et autres

SUMMARY The microbiome is associated with health and disease, but causal effects are hard to quantify— especially in humans where controlled experiments are nearly impossible. Akin to natural experiments, closely monitored patients offer an alternative to characterize microbiome effects. We present TaxUMAP, …

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A compilation of fecal microbiome shotgun metagenomics from hematopoietic cell transplantation patients

Jinyuan Yan, Chen Liao, Bradford P. Taylor, Emily Fontana et autres

Hospitalized patients receiving hematopoietic cell transplants provide a unique opportunity to study the human gut microbiome. We previously compiled a large-scale longitudinal dataset of fecal microbiota and associated metadata, but we had limited that analysis to taxonomic composition of bacteria from 16S …

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Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation

Christopher J. Severyn, Benjamin A. Siranosian, Sandra Tian-Jiao Kong, Ángel Moreno et autres

BACKGROUNDGut decontamination (GD) can decrease the incidence and severity of acute graft-versus-host disease (aGVHD) in murine models of allogeneic hematopoietic cell transplantation (HCT). In this pilot study, we examined the impact of GD on gut microbiome composition and the incidence of aGVHD …

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Impact of Gut Decontamination on the Microbiome and Risk of Bloodstream Infections during Pediatric Allogeneic Hematopoietic Stem Cell Transplantation

Christopher J. Severyn, Benjamin A. Siranosian, Sandra Tian-Jiao Kong, Michelle M. Li et autres

Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

Benjamin A. Siranosian, Erin F. Brooks, Tessa M. Andermann, Andrew R. Rezvani et autres

Bacterial bloodstream infections are a major cause of morbidity and mortality among patients undergoing hematopoietic cell transplantation (HCT). Although previous research has demonstrated that pathogens may translocate from the gut microbiome into the bloodstream to cause infections, the mechanisms by which HCT …

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Randomized controlled trial of gut decontamination in pediatric patients undergoing allogeneic hematopoietic cell transplantation

Christopher J. Severyn, Benjamin A. Siranosian, Sandra Tian-Jiao Kong, Ángel Moreno et autres

ABSTRACT Background Gut decontamination (GD) can decrease the incidence and severity of acute graft- versus-host-disease (aGVHD) in murine models of allogeneic hematopoietic cell transplantation (HCT). Several HCT centers standardly practice GD with different antibiotic regimens. In this pilot study, we examined the …

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MAGs associated with Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

Benjamin A. Siranosian

Assembled genomes from microbiome samples from HCT patients.

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MAGs associated with Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

Benjamin A. Siranosian

Assembled genomes from microbiome samples from HCT patients.

us (code pays fourni par la source)

Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

Benjamin A. Siranosian

Bacterial bloodstream infections are a major cause of morbidity and mortality among patients undergoing hematopoietic cell transplantation (HCT). Although previous research has demonstrated that pathogenic organisms may translocate from the gut microbiome into the bloodstream to cause infections, the mechanisms by which …