Yosuke Suzuki

Perinatal Changes in Serum Fibroblast Growth Factor 21 and Their Association With Postpartum Insulin Resistance in Women With Gestational Diabetes Mellitus

Yosuke Suzuki, Akihito Morita, Jun Okaniwa, Ayuko Tanaka et autres

AIM: This study aimed to clarify the clinical significance of perinatal changes in fibroblast growth factor 21 and their association with postpartum metabolic outcomes in women with gestational diabetes mellitus. METHODS: This single-center retrospective observational study used prospectively collected residual serum samples …

jp (code pays fourni par la source)

Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort

Ryota Tanaka, Yosuke Suzuki, Teruhide Koyama, Takahiro Sumimoto et autres

PURPOSE: CYP3A4 and CYP3A5 are major drug‑metabolizing enzymes that require electrons supplied by P450 oxidoreductase (POR) for catalytic cycle. CYP3A expression is regulated by the nuclear receptors; constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Single-nucleotide polymorphisms (SNPs) of CYP3A5, CYP3A4, …

jp (code pays fourni par la source)

Impact of Lenvatinib on OATP1B Activity in Patients with Hepatocellular Carcinoma

Ken Shiraiwa, Yoshio Sueshige, Ryota Tanaka, Yosuke Suzuki et autres

Aims: Lenvatinib (LEN) inhibits organic anion transporting polypeptide 1B1 (OATP1B1) in vitro, raising concerns about potential risk for transporter-mediated drug–drug interactions (DDIs). This study evaluated the in vivo impact of LEN on OATP1B activity in patients with hepatocellular carcinoma (HCC), using coproporphyrin-I …

jp (code pays fourni par la source)

Plasma Mid-Regional Pro-adrenomedullin as a Prognostic Biomarker in Hematopoietic Stem Cell Transplant Recipients with Febrile Neutropenia

Motoshi Iwao, Ryota Tanaka, Ken Shiraiwa, Yoshio Sueshige et autres

This study aimed to elucidate the association between mid-regional pro-adrenomedullin (MR-proADM) levels at the onset of febrile neutropenia (FN) and clinical outcomes in patients with hematological malignancy undergoing hematopoietic stem cell transplantation (HSCT), and the prognostic performance of MR-proADM compared with established …

jp (code pays fourni par la source)

Proanthocyanidin-rich fractions prepared from blueberry leaf hot-water extracts inhibits interleukin-1β production in RAW264 cells and induces autophagy

Naoya Takehara, Naoki Kodama, Natsuko Tanaka, Chu-shin Kyoku et autres

Blueberry leaves (Vaccinium virgatum Aiton), cultivated in Miyazaki Prefecture, Japan, represent a promising natural health-promoting resource. This study investigated the anti-inflammatory effects of blueberry leaf extract (BLEx) using lipopolysaccharide-stimulated RAW264 macrophage cells. BLEx (up to 100 μg/mL) significantly suppressed nitric oxide production …

jp, om (code pays fourni par la source)

Post‑transplant trajectories and renal function associations of mid‑regional pro‑adrenomedullin, mid‑regional pro‑atrial natriuretic peptide, and copeptin in kidney transplant recipients

Motoshi Iwao, Ryota Tanaka, Yosuke Suzuki, Ayako Oda et autres

jp (code pays fourni par la source)

Plasma coproporphyrins for evaluating OATP1B and OATP2B1 activities: Coproporphyrin-III unsuitable as an OATP2B1 biomarker in Japanese general population

Jun Negami, Yosuke Suzuki, Teruhide Koyama, Miharu Yamazaki et autres

jp (code pays fourni par la source)

Periodic Orbits and Hardware Implementation of Permutation XOR Cellular Automata

Yosuke Suzuki, Toshimichi Saito

This paper studies a permutation XOR cellular automaton: a three-layer dynamical system where the input-tohidden layer corresponds to an elementary cellular automaton of the XOR rule and the hidden-to-output layer is a one-to-one permutation connection. The dynamics is described by an autonomous …

jp (code pays fourni par la source)

Ultra‐Sensitive Quantification of Indoxyl Sulfate and 3‐Carboxy‐4‐Methyl‐5‐Propyl‐2‐Furanpropanoic Acid in Plasma Using Ultra‐Performance Liquid Chromatography Coupled to Quadrupole Time‐of‐Flight Mass Spectrometry

Jun Negami, Yosuke Suzuki, Haruki Sato, Daiki Toyama et autres

BACKGROUND: Uremic toxins such as indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are accumulated in patients with chronic kidney disease (CKD). Recent studies have shown that the accumulation of indoxyl sulfate and CMPF alters the activity of organic anion transporting polypeptide (OATP) 1B …

jp (code pays fourni par la source)

Evaluation of the Adverse Effects of Bosentan in Combination with Clarithromycin

Motoshi Iwao, Ryota Tanaka, Yosuke Suzuki, Ryosuke Tatsuta et autres

The elimination of bosentan (BOSE) is involved in several metabolic enzymes and transporters, including CYP3A4 and OATP1B1/3. Clarithromycin (CAM) has the potential to inhibit these activities, leading to an approximately threefold increase in BOSE exposure when combined. Hepatic impairment, a common adverse …

jp (code pays fourni par la source)

Ultra-sensitive Quantification of Mid-regional Proadrenomedullin in Human Plasma Using Micro-liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry

Yosuke Suzuki, Teruhide Koyama, Jun Negami, Daiki Toyama et autres

High Resolution Image Download MS PowerPoint Slide Mid-regional proadrenomedullin (MR-proADM) has been suggested to be a powerful biomarker for the onset, progression, and mortality of various diseases. To achieve sensitive quantification of MR-proADM without cross-reactivity, we established micro-liquid chromatography coupled to the …

jp (code pays fourni par la source)

InP/Si Integrated Laser With High-Tolerance-Multi-Step-Long-Period Diffraction Grating

Jun‐ichi Suzuki, Masahiro Matsuura, Masakazu Takabahashi, Yosuke Suzuki et autres

We demonstrated a C-band InP/Si integrated laser with a linewidth of about 200 kHz using an optical coupling structure: a high-tolerance-multi-step-long-period diffraction grating (MSLP-DG). This laser cavity was formed by high throughput passive alignment bonding technology by using MSLP-DG structure.

jp (code pays fourni par la source)