Masamitsu Nakao

Validation of the Baveno Endoscopy Avoidance Criteria in Japanese Patients With Chronic Liver Disease: A Real‐World Cohort Study

Maiko Asami, Yoshihito Uchida, Shohei Tsuji, Satsuki Ando et autres

BACKGROUND: The Baveno endoscopy avoidance criteria are widely used to reduce unnecessary screening endoscopy in patients with chronic liver disease. However, evidence regarding their performance in Japanese populations remains limited, and detection-oriented strategies for high-risk varices (HRV) may also be clinically relevant …

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Clinical Outcomes of Gradual Corticosteroid Tapering for Immune Checkpoint Inhibitor‐Induced Liver Injury

Naoto Soma, Yoshihito Uchida, Kayoko Sugawara, Masamitsu Nakao et autres

BACKGROUND AND AIM: Immune checkpoint inhibitor (ICI)-induced liver injury is a clinically important adverse event that may lead to interruption of anticancer therapy. Although systemic corticosteroids are recommended for severe cases, the optimal corticosteroid tapering strategy for relapse prevention and subsequent ICI …

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Short‐Term Clinical Effects After Switching From Zinc Acetate Hydrate to Zinc Histidine Hydrate in Patients With Chronic Liver Disease

Yoshihito Uchida, Naoto Soma, Shohei Tsuji, Satsuki Ando et autres

BACKGROUND: Zinc deficiency is common in patients with chronic liver disease and is associated with hepatic encephalopathy, malnutrition, and poor prognosis. Zinc histidine hydrate was recently approved in Japan for the treatment of hypozincemia; however, clinical evidence regarding switching from zinc acetate …

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Rifaximin Use Is Associated With Prognosis and Recurrence Patterns in Spontaneous Bacterial Peritonitis: Exploratory Insights Into the Oral–Gut–Hepatic Axis

Yoshihito Uchida, Naoto Soma, Shunsuke Yamada, Shohei Tsuji et autres

Background: Spontaneous bacterial peritonitis (SBP) remains a life-threatening complication in cirrhotic patients with refractory ascites. Evidence for rifaximin (RFX) in SBP prevention and prognosis is lacking in Japan. We investigated the effect of RFX on prognosis and recurrence of SBP and evaluated …

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[A case presenting with abdominal pain, jaundice, and anemia on a cold night].

Suguru Mizuno, Nanase Usui, Satsuki Ando, Masamitsu Nakao et autres

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A case of non-HIV pneumocystis pneumonia in a patient with cirrhosis-associated immune dysfunction

Yoshihito Uchida, Shohei Tsuji, Mie Inao, Kayoko Sugawara et autres

A 55-year-old man with a 13-year history of alcohol-related cirrhosis was admitted for the management of refractory ascites. On day 4 of hospitalization, he developed dyspnea, and chest computed tomography (CT) revealed ground-glass opacities and reticular shadows in both lungs, predominantly in …

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Nationwide survey of patients with acute liver failure and late‐onset hepatic failure in Japan seen between 2016 and 2021

Nobuaki Nakayama, Masamitsu Nakao, Yoshihito Uchida, Akio Ido et autres

AIM: A nationwide survey was conducted to clarify the recent status of patients with acute liver failure (ALF) and late-onset fulminant hepatitis (LOHF) in Japan. METHODS: Two-step surveys were performed annually targeting 782 hospitals, focusing on patients meeting the Japanese diagnostic criteria. …

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Endoscopic management of primary sclerosing cholangitis

Suguru Mizuno, Yoshihito Uchida, Satsuki Ando, Masamitsu Nakao et autres

Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has …

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Serum zinc levels as predictors of covert hepatic encephalopathy in patients with liver cirrhosis

Yoshihito Uchida, Jun‐ichi Kouyama, Kayoko Naiki, Aya Sato et autres

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Significance of portal venous blood flow as a factor to determine liver function in patients with decompensated cirrhosis due to hepatitis C virus infection following achievement of sustained viral response by sofosbuvir plus velpatasvir

Yoshihito Uchida, Yukinori Imai, Shohei Tsuji, Hayato Uemura et autres

AIM: To determine the outcomes concerning portal venous blood flow and portosystemic shunts in patients with decompensated cirrhosis due to hepatitis C virus (HCV) infection who achieved sustained viral response (SVR) following antiviral therapy. METHODS: Portal hypertension-related events and liver function were …

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Portal venous blood flows determine liver function in patients with decompensated cirrhosis due to HCV infection receiving successful sofosbuvir/velpatasvir therapy

Yoshihito Uchida, Yukinori Imai, Shohei Tsuji, Hayato Uemura et autres

Abstract Aim: To determine the significance of the portal venous blood flow and portosystemic shunts in patients with decompensated cirrhosis due to HCV infection following SVR achievement.Methods: Portal hypertension-related events and liver function were evaluated in 27 patients during and after sofosbuvir/velpatasvir …

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Superiority of tenofovir alafenamide fumarate over entecavir for serum HBsAg level reduction in patients with chronic HBV infection: A 144-week outcome study after switching of the nucleos(t)ide analog

Yoshihito Uchida, Masamitsu Nakao, Shunsuke Yamada, Shohei Tsuji et autres

BACKGROUND: To evaluate the long-term efficacy of switching of the nucleos(t)ide analog used for treatment from entecavir (ETV) to tenofovir alafenamide fumarate (TAF) in patients with chronic HBV infection. METHODS: A total of 103 patients with serum HBsAg levels of ≥100 IU/mL …

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