Domenico De Donatis

Cannabis Use and Clinical Outcomes in First Episode Psychosis: Results From a 2‐Year Follow‐Up Study

Ilaria Domenicano, Alice Onofrio, Domenico De Donatis, Sara Malservigi et autres

AIM: This study aimed to investigate the association between cannabis use prior to enrollment in a First Episode Psychosis (FEP) program and prognosis, including severity of psychiatric symptoms, type of antipsychotic treatment prescribed, and clinical recovery. METHODS: A longitudinal cohort study was …

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Sex differences in outcomes of first episode psychosis: results from an early intervention service

Ilaria Domenicano, Alice Onofrio, Martina Citton, Ludovica Vecchioni et autres

Background Early intervention services (EIS) for first-episode psychosis (FEP) play a key role in shaping a better disease trajectory for both affective and non-affective psychosis. Psychotic disorders tend to present sex differences both from an epidemiological and clinical perspective. Aims The primary …

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Mirtazapine blood levels and antidepressant response

Domenico De Donatis, Marco Verrastro, Giuseppe Fanelli, Chiara Fabbri et autres

OBJECTIVE: Therapeutic drug monitoring (TDM) is an important tool for treatment optimisation. Its usefulness has recently been demonstrated for some first-line antidepressants; however, few studies have been reported on the relationship between blood levels of mirtazapine and its antidepressant effects. The aim …

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Mirtazapine blood levels and antidepressant response

Domenico De Donatis, Marco Verrastro, Giuseppe Fanelli, Chiara Fabbri et autres

Pharmacological approaches to the management of panic disorder in older patients: a systematic review

Daniela Caldirola, Domenico De Donatis, Alessandra Alciati, Silvia Daccò et autres

INTRODUCTION: Recommendations for treating panic disorder (PD) in older patients are scarce. The authors have systematically reviewed whether several recommended medications are superior to others and their optimal doses in this age group. METHODS: A database search of studies involving patients with …

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Cardiorespiratory Assessments in Panic Disorder Facilitated by Wearable Devices: A Systematic Review and Brief Comparison of the Wearable Zephyr BioPatch with the Quark-b2 Stationary Testing System

Daniela Caldirola, Silvia Daccò, Massimiliano Grassi, Alessandra Alciati et autres

Abnormalities in cardiorespiratory measurements have repeatedly been found in patients with panic disorder (PD) during laboratory-based assessments. However, recordings performed outside laboratory settings are required to test the ecological validity of these findings. Wearable devices, such as sensor-imbedded garments, biopatches, and smartwatches, …

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Therapeutic Drug Monitoring of Antidepressants: An Underused but Potentially Valuable Tool in Primary Care

Daria Piacentino, Esperia Bianchi, Domenico De Donatis, Vincenzo De Florio et autres

Depressive disorders are among the most burdensome diseases globally in terms of prevalence, as well as in terms of quality of life, morbidity, and mortality. Hence, it is becoming increasingly common for primary care physicians to administer and monitor the treatment of …

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Antidepressant efficacy is correlated with plasma levels: mega-analysis and further evidence.

Lorenzo Cellini, Domenico De Donatis, Gerald Zernig, Diana De Ronchi et autres

The debate around optimal target dose for first-line antidepressants (ADs) is still ongoing. Along this line, therapeutic drug monitoring (TDM) represents one of the most promising tools to improve clinical outcome. Nevertheless, a few data exist regarding the concentration-effect relationship of first-line …

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Social withdrawal and neurocognitive correlates in schizophrenia

Domenico De Donatis, Stefano Porcelli, Diana De Ronchi, Emilio Merlo Pich et autres

Poor neurocognitive performance has been associated with poor functional outcome in schizophrenia (SCZ) in past studies. Nonetheless, the likely association between neurocognition and social withdrawal has never been investigated. The aim of our study was to investigate in a large and heterogeneous …

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Antidepressant efficacy is correlated with plasma levels: mega-analysis and further evidence

Lorenzo Cellini, Domenico De Donatis, Gerald Zernig, Diana De Ronchi et autres

The debate around optimal target dose for first-line antidepressants (ADs) is still ongoing. Along this line, therapeutic drug monitoring (TDM) represents one of the most promising tools to improve clinical outcome. Nevertheless, a few data exist regarding the concentration-effect relationship of first-line …

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Switch to 3-Month Long-Acting Injectable Paliperidone May Decrease Plasma Levels

Lorenzo Cellini, Domenico De Donatis, Laura Mercolini, Fabio Panariello et autres

Cellini, Lorenzo MD; De Donatis, Domenico MD; Mercolini, Laura PhD; Panariello, Fabio MD, PhD; De Ronchi, Diana MD, PhD; Serretti, Alessandro MD, PhD; Conca, Andreas MD, PhD; Gaspari, Davide MD; Giupponi, Giancarlo MD; Zernig, Gerald MD; Florio, Vincenzo MD Author Information

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Venlafaxine and O-desmethylvenlafaxine serum levels are positively associated with antidepressant response in elder depressed out-patients

Domenico De Donatis, Stefano Porcelli, Gerald Zernig, Laura Mercolini et autres

BACKGROUND: Therapeutic Drug Monitoring (TDM) represents one of the most promising tools in clinical practice to optimise antidepressant treatment. Nevertheless, little is still known regarding the relationship between clinical efficacy and serum concentration of venlafaxine (VEN). The aim of our study was …

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