Jinrui Cui

Association between pre-pregnancy body mass index and neonatal outcomes in women undergoing assisted reproductive technology: a retrospective study

Qian Hu, Yunyun Wang, Caiying Bai, Lina Gao et autres

OBJECTIVE: ART and pre-pregnancy BMI are strongly associated with neonatal outcomes, but there are fewer relevant studies. Our objective was to analyze the association between pre-pregnancy body mass index (BMI) and neonatal outcomes in women planning assisted reproductive technology (ART). METHODS: ): …

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Exercise Training Modalities in Young and Middle‐Aged Adults With Prehypertension or Hypertension: A Systematic Review and Network Meta‐Analysis

Lu Tian, Siyu Yang, Yan Ping Hu, Jinrui Cui et autres

Aims: The question of how to choose the right type of exercise to lower blood pressure and cardiovascular risk factors in people worldwide with high blood pressure is not yet fully understood. Thus, the aim of this study was to investigate the …

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Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes

Magdalena del Rocío Sevilla-González, Kirk Smith, Ningyuan Wang, Aubrey E. Jensen et autres

Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with …

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Structural equation modeling analysis of factors influencing decisional conflict between dialysis modality among end-stage kidney disease patients in Wuhan

Shiyi Zhang, Jinrui Cui, Xiaoqin Liu, Xifei He et autres

OBJECTIVES: To explore the influencing factors and relationships associated with decisional conflict of dialysis modality in End-stage kidney disease (ESKD) patients. METHODS: This study was a survey-based cross-sectional investigation conducted on 150 ESKD patients in a third-class hospital in Wuhan. The general …

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Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta

Tania L Gonzalez, Bryn Erin Willson, Erica T. Wang, Kent D. Taylor et autres

BACKGROUND: Fetal sex and placental development impact pregnancy outcomes and fetal-maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies. METHODS: Pregnant subjects were recruited in late first trimester (weeks 10-14) at time of chorionic …

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Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry

Kharis A. Burns, Benjamin H. Mullin, Loes M E Moolhuijsen, Triin Laisk et autres

Abstract Background Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are heterogeneous with notable differences between lean and obese women, implying a different pathophysiology manifesting in differential body mass index …

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor et autres

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms that are often specific to cell type 3,4 . Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate …

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Heterogeneous effects on type 2 diabetes and cardiovascular outcomes of genetic variants and traits associated with fasting insulin.

Alisa Knodle Manning, Magdalena del Rocío Sevilla-González, Kirk Smith, Ningyuan Wang et autres

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Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor et autres

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. …

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Infertility and treatments used have minimal effects on first-trimester placental DNA methylation and gene expression

Tania L Gonzalez, Amelia M. Schaub, Bora Lee, Jinrui Cui et autres

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DNA METHYLATION CHANGES IN EARLY PLACENTA FROM ASSISTED REPRODUCTIVE TECHNOLOGIES ARE NOT ASSOCIATED WITH SIGNIFICANT GENE EXPRESSION CHANGES

Amelia M. Schaub, Tania L Gonzalez, Jinrui Cui, Mark O. Goodarzi et autres

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Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Jinrui Cui, Gautam Ramesh, Martin Wu, Elizabeth T. Jensen et autres

Gut microbiome studies have documented depletion of butyrate-producing taxa in type 2 diabetes. We analyzed associations between butyrate-producing taxa and detailed measures of insulin homeostasis whose dysfunction underlies diabetes in 224 non-Hispanic Whites and 129 African Americans, all of whom completed an …