Accès ouvert
2025
article
OpenAlex
Aaron Winer, Emily Ferguson Mason, Alexander G. Bick, Michael Robert Savona et autres
• ANKRD26 VUSs complicate risk assessment in hematologic malignancy and may extend beyond the known pathogenic hot spot. • Unexpected germ line findings from next-generation sequencing highlight the need for clearer guidance in interpreting and managing VUSs. ANKRD26 -related thrombocytopenia ( ANKRD26 …
us
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Accès ouvert
2023
preprint
OpenAlex
Vindhya Vijay, Amy M. Meacham, Lauren M. Katzell, Aaron Winer et autres
ABSTRACT Refractory disease is the greatest challenge in acute myeloid leukaemia (AML). Previously, we found vascular-associated AML cells as a source for refractory disease. In this study we use a bioassay of AML cells co-cultured on bone marrow-derived endothelial cells (BMECs) to …
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2023
article
OpenAlex
Akshay Mathavan, Akash Mathavan, Rodrigo Murillo-Alvarez, Kriti Gera et autres
us
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2023
article
OpenAlex
Akash Mathavan, Akshay Mathavan, Mohit Mathavan, Urszula Krekora et autres
Background Sickle cell disease (SCD) is a diverse group of blood disorders with significant global disease burden. Contemporary interest in the underlying inflammatory paradigm of SCD has emphasized the role of the neutrophil–lymphocyte ratio (NLR) as a prognostic inflammatory marker.Methods We retrospectively …
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Accès ouvert
2022
article
OpenAlex
Abhinav Karan, Hui Jun Guo, Aaron Winer, Mike Ghobrial et autres
Diabetes insipidus is a rarely encountered cause of hypernatremia, often presenting a diagnostic and therapeutic dilemma for the encountering physician. Patients are often asymptomatic for a number of years due to compensation of their polyuria with polydipsia, but may have dramatic presentations …
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2019
conference-abstract
OpenAlex
Vindhya Vijay, Amy M. Meacham, Lauren Katzell, Aaron Winer et autres
Abstract Refractory and relapsed disease is the greatest challenge in acute myeloid leukemia (AML), and we have shown that blood vessels serve as sanctuary sites for AML. Using a high throughput screening assay mimicking AML in the vascular niche, we screened 31 …
us
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2019
conference-abstract
OpenAlex
Vindhya Vijay, Amy M. Meacham, Lauren Katzell, Aaron Winer et autres
Refractory and relapsed disease is the greatest challenge in acute myeloid leukemia (AML), and we have shown that blood vessels serve as sanctuary sites for AML. Using a high throughput screening assay mimicking AML in the vascular niche, we screened 31 million …
us
(code pays fourni par la source)
Accès ouvert
1983
article
OpenAlex
William J. Riley, Aaron Winer, David L. Goldstein
us
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