Impact of genotype on clinical course in sickle cell disease and the utility of neutrophil-lymphocyte ratio: a ten-year single-institution experience
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Le résumé fourni par la source
Background Sickle cell disease (SCD) is a diverse group of blood disorders with significant global disease burden. Contemporary interest in the underlying inflammatory paradigm of SCD has emphasized the role of the neutrophil–lymphocyte ratio (NLR) as a prognostic inflammatory marker.Methods We retrospectively reviewed 268 hospitalized patients with SCDs of different genotypes (HbSS, HbSβ0 thalassemia, HbSβ+ thalassemia, and HbSC), totaling 3329 hospital admissions over a 10-year period. Patients were stratified into SS/Sβ0 and Sβ+/SC groups for statistical analysis of parameters collected at steady state and at hospital admission.Results At steady state, per unit increase of hemoglobin values was associated with reduced odds of ≥ 2 hospital admissions per year in SS/Sβ0 and Sβ+/SC groups; per unit increase in platelet count and white blood cell count was associated with increased odds only in the SS/Sβ0 group. The NLR had no association in either group. During admission, a cutoff of NLR = 3.5 discerned infection with a sensitivity of 60% and specificity of 57%. Performance improved when excluding patients on outpatient hydroxyurea therapy (cutoff of NLR = 3.5; sensitivity of 68% and specificity of 64%).Conclusion This study supports the utility of NLR as an accessible adjunctive clinical tool in SCD prognostication.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of genotype on clinical course in sickle cell disease and the utility of neutrophil-lymphocyte ratio: a ten-year single-institution experience
- Date Crossref
- 04/07/2023
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Florida Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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St. George's School pays non établi dans la noticeUniversité ou école supérieure
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University of Central Florida Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Florida College pays non établi dans la noticeUniversité ou école supérieure
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St George’s University School of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Internal Medicine — University of Florida, St. George's School et Department of Medicine — University of Central Florida, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.