Cassie Moats

OP 6.7 – 00044 Long-term ART-free SIV Remission Following Allogeneic Hematopoietic Cell Transplantation in Mauritian Cynomolgus Macaques

Helen L. Wu, Mahesh Kumar, Emily J. Fray, Robert F. Siliciano et autres

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Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology

Katharine J. Bar, Ernesto Coronado, Tiffany Hensley‐McBain, Megan A. O’Connor et autres

testing of novel treatments. However, many of the currently available SHIVs have distinct drawbacks and are unable to fully reflect the features characteristic of primary SIV and HIV strains. Here, we utilize rhesus macaques to define the immunopathogenesis of the recently developed …

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Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques

Megan A. O’Connor, Paul V. Munson, Hillary C. Tunggal, Nika Hajari et autres

Depletion of gut T helper 17 (Th17) cells during HIV infection leads to decreased mucosal integrity and increased disease progression. Conversely, T regulatory (Treg) cells may inhibit antiviral responses or immune activation. In HIV elite controllers, a balanced Th17/Treg ratio is maintained …

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Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

Lucrezia Colonna, Christopher W. Peterson, John B. Schell, Judith Carlson et autres

Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the question of whether transplantation can eradicate the HIV reservoir. To test this, we here present a model of allo-HCT in SHIV-infected, cART-suppressed nonhuman primates. We infect rhesus …

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Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller et autres

The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection in humans are unclear. Here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to ZIKV infection are significantly …

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Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Lucrezia Colonna, John B. Schell, Christopher W. Peterson, Judith Carlson et autres

Abstract Background : The Berlin patient is thus far the only individual considered cured of HIV. Three aspects of the Berlin Patient's treatment are thought to have contributed to his cure following allogeneic hematopoietic stem cell transplantation (HCT): 1) the myeloablative conditioning …

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Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Alexander S. Zevin, Cassie Moats, Drew May, Solomon N. Wangari et autres

The mesenteric lymph nodes (MLN) and the liver are exposed to microbes and microbial products from the gastrointestinal (GI) tract, making them immunologically unique. The GI tract and associated MLN are sites of early viral replication in human immunodeficiency virus (HIV) infection …

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Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Alexander S. Zevin, Cassie Moats, Drew May, Solomon N. Wangari et autres

The mesenteric lymph nodes (MLN) and the liver are exposed to microbes and microbial products from the gastrointestinal (GI) tract, making them immunologically unique. The GI tract and associated MLN are sites of early viral replication in human immunodeficiency virus (HIV) infection …

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