Leigh B. Latham

Cerebral blood flow is associated with markers of neurodegeneration in Huntington’s disease

Natália Pessoa Rocha, Odelin Charron, Gabriela Delevati Colpo, Leigh B. Latham et autres

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Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

Lucas Miranda Kangussu, Natália Pessoa Rocha, Priscila Aparecida Costa Valadão, Thatiane C. G. Machado et autres

The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical and experimental studies have suggested that alterations in the brain RAS contribute to the development and progression of neurodegenerative diseases. …

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Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology

Natália Pessoa Rocha, Odelin Charron, Leigh B. Latham, Gabriela Delevati Colpo et autres

OBJECTIVE: To define the role played by microglia in different stages of Huntington disease (HD), we used the TSPO radioligand [11C]-ER176 and PET to evaluate microglial activation in relation to neurodegeneration and in relation to the clinical features seen at premanifest and …

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Microglia activation in basal ganglia is a late event in Huntington’s disease pathophysiology (2626)

Erin E. Furr-Stimming, Leigh B. Latham, Odelin Charron, Gabriela Delevati Colpo et autres

To investigate structural and functional changes in microglia in different stages of HD.

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Decreased cerebral blood flow in the striatum is an early event in Huntington’s disease pathology (P1.8-044)

Erin E. Furr-Stimming, Natália Pessoa Rocha, Leigh B. Latham, Odelin Charron et autres

This study was designed to investigate cerebral blood flow (CBF) changes in HD patients and premanifest HD gene carriers.

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Exploring the relationship between brain atrophy and clinical symptoms in Huntington’s disease (S41.009)

Erin E. Furr-Stimming, Gabriela Delevati Colpo, Natália Pessoa Rocha, Leigh B. Latham et autres

To determine whether brain regional volumes are associated with HD clinical symptoms.

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Pharmacologic chaos: severe hypotension from interactions of anesthetics, marijuana, amphetamines, and paroxetine

Anne E. Cossu, Leigh B. Latham, Doris M. Hardacker, Andrew H. Jea

Antivirus immune activity in multiple sclerosis correlates with MRI activity

Leigh B. Latham, Men-Jean Lee, John A. Lincoln, Niannian Ji et autres

OBJECTIVE: The objective of this study was to determine whether reactivation of Epstein-Barr (EBV) or activation of the anti-EBV immune response correlates with MS disease activity on MR imaging. METHODS: Subjects with early, active relapsing-remitting MS were studied for 16 weeks with …

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Immunoglobulin E-Mediated Anaphylaxis on the Tenth Exposure to Cisatracurium in a 4-Year-Old Child

Robin DeCoursey Jenson, Leigh B. Latham, Girish V. Vitalpur, Stephen F. Dierdorf

A 4-year-old female developed hypotension, tachycardia, hypoxemia, and diffuse erythema after induction of anesthesia with ketamine, fentanyl, and cisatracurium. Treatment consisted of repeated doses of epinephrine, diphenhydramine, corticosteroids, and IV fluids. Skin prick testing performed 4 weeks after the incident confirmed an …

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Variability of Epstein-Barr Virus Activity and the Anti-EBV Immune Response in Multiple Sclerosis (P05.163)

John William Lindsey, Leigh B. Latham

OBJECTIVE: To determine if reactivation of Epstein-Barr virus (EBV) drives disease activity in multiple sclerosis (MS).

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PREANESTHETIC EVALUATION

Leigh B. Latham

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