Accès ouvert
2026
article
OpenAlex
Eunyoung Lee, Gabriela Delevati Colpo, Lucy Couture, Laurence S. Baskin et autres
Background There is limited long-term prospective data on post-COVID-19 neuropsychiatric symptoms (NPS), hindering our understanding of symptom progression beyond 12 months. The biological mechanisms behind persistent NPS remain unclear, with most hypotheses based on acute-phase data. This study examined the longitudinal associations …
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Accès ouvert
2026
article
OpenAlex
Eunyoung A. Lee, Maria Paula Maziero, Livia C. Merrill, Gabriela Delevati Colpo et autres
Background: A substantial proportion of individuals hospitalized for COVID 19 experience persistent neurological and psychiatric symptoms. The long-term trajectories of these symptoms, collectively referred to as neuropsychiatric manifestation of Post-Acute Sequelae of COVID-19 (Neuro-PASC), and their association with cognitive outcomes remains poorly …
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Accès ouvert
2026
preprint
OpenAlex
Jacob Hudobenko, Eunyoung Angela Lee, Gabriela Delevati Colpo, Louise Atadja et autres
Post-stroke inflammation contributes to poor outcomes in both clinical and experimental studies. Interleukin-6 (IL-6) is a key inflammatory mediator in ischemic stroke, and higher circulating IL-6 levels are associated with greater stroke severity and worse clinical outcomes. Targeting IL-6 signaling therefore represents …
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Accès ouvert
2026
article
OpenAlex
Maria Paula Maziero, Eunyoung Angela Lee, Gabriela Delevati Colpo, Lucy Couture et autres
OBJECTIVE: Neurological symptoms are commonly reported among individuals with postacute sequelae of COVID-19 (PASC), with cognitive impairment being the most common feature, but cognitive trajectories in PASC have not been clearly defined. The authors determined long-term cognitive changes in a cohort of …
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2026
article
OpenAlex
Riley Lorenz, Gabriela Delevati Colpo, E Lee, L Baskin et autres
2026
conference-abstract
OpenAlex
Joshia John, Gabriela Delevati Colpo, Lucy Couture, Ana E. Cahuiche et autres
Introduction: Distinguishing the etiology of intracerebral hemorrhage (ICH), whether due to hypertension or cerebral amyloid angiopathy (CAA), remains a critical clinical challenge, particularly as imaging often reveals overlapping pathologies in older adults. Inflammation is central to ICH pathophysiology and may provide diagnostic …
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2026
conference-abstract
OpenAlex
Lucy Couture, Ana Petway, Gabriela Delevati Colpo, Lynae Baskin et autres
Introduction: Epidemiological studies have shown sex differences in stroke prevalence and outcomes. These differences may be attributed, in part, to sex-specific immune responses that alter post-stroke inflammatory events. Inflammation is a hallmark of stroke pathology, and cytokines such as interleukin-6 (IL-6) and …
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2026
conference-abstract
OpenAlex
Lynae Baskin, Lucy Couture, Riley Lorenz, MAYA HOFFMAN et autres
Introduction: Preeclampsia (PreE) is a hypertensive disorder of pregnancy diagnosed after 20 weeks of gestation. While broadly characterized by hypertension (HTN), systemic inflammation, and end-organ injury, PreE varies in severity and presentation, and its impact on maternal brain health remains unclear. Small …
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2026
conference-abstract
OpenAlex
MAYA HOFFMAN, Lucy Couture, Banerjee Ak, Gabriela Delevati Colpo et autres
Introduction: Ischemic stroke initiates a cascade of molecular events including increased neuroinflammation, immune dysregulation, and vascular injury, yet the biological mechanisms of post-stroke recovery remain poorly understood. In both experimental and clinical studies, social isolation (SI) impairs stroke recovery through distinct immunometabolism …
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2026
conference-abstract
OpenAlex
Lucy Couture, Banerjee Ak, Gabriela Delevati Colpo, Patrick D Eagen et autres
Introduction: Social isolation (SI) is psychosocial stress that worsens outcomes in multiple neurological disorders including stroke, especially in the elderly. Previous studies have shown that SI can increase systemic inflammation, cognitive decline, neuropsychiatric symptoms and metabolic disorders. Understanding the non-modifiable (e.g., genetics …
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2026
conference-abstract
OpenAlex
Aditya Kumar, PEDRAM PEESH, Semeon Afework, Romeesa Khan et autres
Introduction: Tissue damage after ischemic stroke triggers a local and systemic inflammatory cascade that contributes significantly to morbidity and mortality after stroke. The contribution of adaptive immunity to the early sequela of ischemic stroke is poorly understood. Prior cerebral ischemia and blood …
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Accès ouvert
2025
article
OpenAlex
Suélyn Koerich, Santiago Ramírez, Natalia Astudillo, Gabriela Delevati Colpo et autres
Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia, marked by the accumulation of extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and neuroinflammation, all contributing to cognitive decline. Although disease‐modifying therapies targeting amyloid plaques show promise, eligibility for these treatments is …
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