Fei Cui

Budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler relieves cough after lobectomy: a randomized controlled study

Junguo Dong, Shunjun Jiang, Yuan Qiu, Jingpei Li et autres

Background: Cough after pulmonary resection (CAP) has emerged as a prevalent complication. However, existing treatment protocols for CAP lack standardization. The components of the budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler (BGF MDI) have been consistently documented for their effectiveness in cough management. …

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Synthesis and Antitumor Activity of Novel 1,3-Disubstituted Pyridazinone Derivatives

Luye Zhang, Yang Zhang, Chongnan Bao, Peng Yang et autres

为了寻找高效低毒的抗肿瘤药物，设计并合成新型的1，3位取代酞嗪酮类化合物.采用噻唑蓝（MTT）法对目标化合物在MCF-7（人乳腺癌细胞）、PC-3（人前列腺癌细胞）、SW-620（人结肠癌细胞）和HGC-27（人胃癌细胞）四种人类癌细胞的抗增殖活性进行评价.结果显示大部分化合物具有较好的抗增殖活性.其中，2-（4-（4-溴苯基）-1-氧代酞嗪-2（1H）-基）-N-（2-氟苯基）乙酰胺（5g）对MCF-7细胞的抗增殖活性较好，IC50值为6.01 μmol/L，为抗肿瘤药物的研究提供了思路.

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Synthesis and Antitumor Activities of Novel 1,2,3-Triazolo[4,5-d]pyrimidine Derivatives

Na Li, Jingchao Xin, Qisheng Ma, Erdong Li et autres

为了寻找高效的抗肿瘤药物，设计并合成了一系列新型的1，2，3-三氮唑[4，5- d ]嘧啶类衍生物，对这些化合物在人类五种癌细胞MGC-803（人胃癌细胞）、MCF-7（人乳腺癌细胞）、EC-109（人食管癌细胞）、PC-3（人前列腺癌细胞）、Hela（人宫颈癌细胞）进行抗肿瘤活性评价，结果显示大部分化合物具有较好的抗肿瘤活性，其中5-（（（1 H -苯并[ d ]咪唑-2-基）甲基）硫基）-3-苄基- N -（4-氯苯基）-3 H -[1, 2, 3]-三氮唑[4，5- d ]嘧啶-7-胺（ 11b ）和2，2'-（（5-（（（1 H -苯并[ d ]咪唑-2-基）甲基）硫基）-3-苄基-3 H -[1, 2, 3]-三氮唑[4，5- d ]嘧啶-7-基）氮烷二基）双（乙烷-1-醇）（ 11m ）对MGC-803和Hela癌细胞的抗肿瘤活性优于对照品氟尿嘧啶.

Synthesis and Antitumor Evaluation of 2,4-Substituted Quinazoline Derivatives Containing Benzimidazole

Na Li, Jingchao Xin, Yaqi Meng, Erdong Li et autres

Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3‐Triazole Linked Quinazoline Derivatives

Panpan Song, Fei Cui, Na Li, Jingchao Xin et autres

A series of novel 1,2,3‐triazole‐quinazoline derivatives were synthesized in five steps starting from anthranilamide by conventional methods. All the title compounds 10a — 10r were evaluated for cytotoxic activity against four human cancer cell lines ( MGC ‐803, EC ‐109, MCF ‐7 …

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Synthesis and Antitumor Activity Evaluation of 2,4,6-Trisubstituted Pyrimidine Derivatives

Panpan Song, Na Li, Fei Cui, Jingchao Xin et autres

With the aim of obtaining potential antitumor candidates with more efficiency and more economic value.40 2,4,6-trisubstituted pyrimidine derivatives bearing chalcone moiety were synthesized via cyclization, chlorination, substitution with benzoylacetate and ethylacetoacetate as the starting materials.The structures of target products were confirmed by …

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Synthesis and Antitumor Activity Evaluation of 3,6-Substituted- 1,2,4-triazolo[3,4-a]phthalazine Derivatives

Chaojie Wang, Qinpo Cao, Hui Yang, Panpan Song et autres

With the aim of obtaining potential antitumor candidates with more efficiency and more economic value. A series of 3,6-substituted-1,2,4-triazolo(3,4-a)phthalazine derivatives were synthesized. The target products were obtained via cycliza- tion, chlorination, substitution, cyclization, substituted with phthalic anhydride used as the starting material. …