Per Kristian Eide

Low-rank tensor decompositions reveal coupled spatiotemporal patterns of CSF tracer transport in the human brain

Andreas Solheim, Geir André Ringstad, Per Kristian Eide, Marie Elisabeth Rognes et autres

Intrathecal contrast-enhanced longitudinal MRI, or glymphatic MRI (gMRI), provides a unique clinical window into human cerebrospinal fluid (CSF) transport, interstitial fluid (ISF) interaction, and the glymphatic system. However, standard analyses flatten these multi-subject longitudinal data into univariate comparisons across regions of interest, …

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Forecasting Intrathecal Tracer Enhancement from Pre-Contrast Brain MRI: Direct Regression versus Flow Matching

Qinghui Liu, Jon André Ottesen, Thu Van Nguyen, Geir Ringstad et autres

Intrathecal contrast-enhanced MRI tracks how a cerebrospinal-fluid tracer spreads through the brain, but requires repeated scans over 24--48\,h. Forecasting enhancement from a pre-contrast scan could one day help select patients for intrathecal drug treatment and plan their dose. We ask how much …

Low-rank tensor decompositions reveal coupled spatiotemporal patterns of CSF tracer transport in the human brain

Andreas Solheim, Geir André Ringstad, Per Kristian Eide, Marie Elisabeth Rognes et autres

Raw data results from the paper: Low-rank tensor decompositions reveal coupled spatiotemporal patterns of CSF tracer transport in the human brain This project contains the time and spatial modes computed for the various dataset splits discussed in this work. The subject mode …

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Context-dependent localization and expression of glutamate and GABA and their machinery in microglia

Carl Johan Sogn, Miko Valori, Pål Rønning, Per Kristian Eide et autres

Microglia are central regulators of brain homeostasis and synaptic architecture, but whether they, like astrocytes, act as reservoirs and handlers of glutamate and GABA is unknown. Using post-embedding immunogold electron microscopy, we provide the first ultrastructural evidence that individual microglial processes contain …

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Cognitive profiles in idiopathic normal pressure hydrocephalus and Alzheimer's disease

Magnhild S. Dejgaard, Per Kristian Eide, Gro Gujord Tangen, Eva Skovlund et autres

BackgroundIdiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) are neurodegenerative disorders with partly overlapping clinical features. Since the treatment is different, we need better knowledge about how the cognitive profile differs between these conditions.ObjectiveWe aimed to compare the cognitive profile of …

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Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research

Heikki Lukkarinen, Antti Johannes Luikku, Antonios Dougalis, Anssi Pelkonen et autres

Abstract Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibrillary tau …

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Non-invasive characterization of perivascular subarachnoid spaces

Nina E. Fultz, Geir André Ringstad, Maddalena Debiasi, Emiel C. A. Roefs et autres

Abstract Cerebrospinal fluid (CSF) is thought to facilitate brain waste clearance and immune surveillance, yet its compartmentalization remains unclear. Previous work, using invasive dynamic intrathecal MRI contrast imaging, identified a perivascular subarachnoid space (PVSAS) that enhances along the major cerebral arteries with …

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Intracranial hemorrhagic risk after cortical brain biopsy during shunt surgery for idiopathic normal pressure hydrocephalus: a prospective comparative study

Per Kristian Eide, Aslan Lashkarivand

BACKGROUND: This study prospectively compared postoperative intracranial hemorrhagic complications following shunt surgery for idiopathic normal pressure hydrocephalus (iNPH) in patients undergoing the procedure with or without a concomitant cortical brain biopsy. METHODS: All patients undergoing shunt surgery for iNPH at our institution …

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Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus

Per Kristian Eide, Alexander Gul Sherwani, Luis Romundstad, Jan Gunnar Fjeld et autres

Water exchange between cerebrospinal fluid (CSF) and blood is fundamental to brain fluid homeostasis, yet ventricular CSF-to-blood water transport has never been quantified as a physiological parameter in adult humans. We investigated ventricular water absorption kinetics in 40 adults undergoing diagnostic evaluation …

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Estimation of human brain fluid clearance using intrathecal imaging contrast agents

Per Kristian Eide, Aslan Lashkarivand, Susanne Sørensen Hernes, Geir Ringstad et autres

BACKGROUND: Extra-vascular brain fluid dynamics, including exchange through glymphatic and meningeal lymphatic pathways, has been proposed essential for waste clearance and solute transport in the central nervous system. Although animal studies provide evidence for these pathways' role in clearing neurotoxic proteins and …

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Exploring Lymphovenous Anastomosis for Alzheimer’s Disease: Addressing Brain Lymphatic Dysfunction, Feasibility, and Outcome Metrics

Stav Brown, Felix J Klimitz, Jonathan Kipnis, Helene Benveniste et autres

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Cerebrospinal Fluid–Mediated Brain Clearance: Insights from Human Studies

Per Kristian Eide, César Luis Vera Quesada, Geir André Ringstad

Clearance of waste products from brain metabolism and by-products of brain injury is a fundamental aspect of normal brain function. Impaired clearance may cause accumulation of proteins and other substances that are harmful to the brain. Abnormal protein aggregation due to clearance …

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