Cognitive profiles in idiopathic normal pressure hydrocephalus and Alzheimer's disease
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Le résumé fourni par la source
BackgroundIdiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) are neurodegenerative disorders with partly overlapping clinical features. Since the treatment is different, we need better knowledge about how the cognitive profile differs between these conditions.ObjectiveWe aimed to compare the cognitive profile of iNPH patients with that of a large cohort of confirmed AD patients.MethodsPatients diagnosed with iNPH and accepted for shunt surgery were compared with patients with biomarker verified Alzheimer's disease in The Norwegian Register of Persons Assessed for Cognitive symptoms (NorCog). All patients underwent a standardized cognitive assessment with age and education adjusted z-scores. We used the Clinical Dementia Rating Scale (CDR) to adjust for disease severity. Since the cognitive score distributions were highly skewed, we used nonparametric analyses stratified by CDR stage combined with multinomial logistic regression.ResultsIn total, 276 iNPH patients were compared to 1113 AD patients. iNPH patients performed significantly poorer on phonemic fluency [median z-score difference (AD-iNPH) 0.30, 95% confidence interval (CI) 0.20 to 0.50], but significantly better on other cognitive tests, in particular immediate (median difference -0.35, 95% CI -0.49 to -0.20) and delayed recall (median difference -0.46, 95% CI -0.59 to -0.34). The differences persisted after adjustment for CDR and were most pronounced in early stages of the disease.ConclusionsiNPH seems to affect phonemic fluency more and memory less than AD. As the disease progresses, the cognitive profiles become more similar, and the conditions cannot be distinguished by cognitive tests.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cognitive profiles in idiopathic normal pressure hydrocephalus and Alzheimer's disease
- Date Crossref
- 28/08/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Oslo University Hospital Department of Geriatric Medicine pays non établi dans la noticeÉtablissement de santé
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University of Oslo Institute of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Sykehuset i Vestfold pays non établi dans la noticeÉtablissement de santé
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Norwegian National Centre for Ageing and Health pays non établi dans la noticeÉtablissement de santé
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Norwegian University of Science and Technology Department of Public Health and Nursing pays non établi dans la noticeUniversité ou école supérieure
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Vestfold Hospital Trust Norwegian National Center for Ageing and Health pays non établi dans la noticeÉtablissement de santé
Department of Geriatric Medicine — Oslo University Hospital, Institute of Clinical Medicine — University of Oslo et Sykehuset i Vestfold, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.