In Sik Kim

Comparative Immunotherapeutic Effects of Der p 1, Der p 2, and Der p 38 in a Murine Model of Dermatophagoides pteronyssinus -induced Eosinophilic Asthma

Min Hwa Hong, In Sik Kim

Objectives: Asthma is a chronic inflammatory airway disease triggered by sensitization to house dust mites.Der p 1, Der p 2, and Der p 38 are major allergens derived from Dermatophagoides pteronyssinus (DP).This study compared the immunotherapeutic effects of DP extract and individual …

kr (code pays fourni par la source)

Integrated Mechanisms Driving Parkinson's Disease Pathogenesis

Ayesha Kashif, In Sik Kim

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the selective degeneration of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of aggregated α-synuclein within Lewy bodies and Lewy neurites.Although traditionally defined by its motor manifestations, PD is …

au, kr (code pays fourni par la source)

Role of CRM1-mediated SFPQ/S100A8 complex formation in psoriasis

Geunyeong Kim, Yujin Hong, Ji-Sook Lee, Juram Lee et autres

kr (code pays fourni par la source)

Interaction of SFPQ with S100A8 and S100A9 in EoL-1 and EoL-1-IR cells

Jae Ha Baek, Geunyeong Kim, Yujin Hong, Min Hwa Hong et autres

kr (code pays fourni par la source)

The Inhibitory Effect of Duchesnea indica Extract on Mixed Granulocytic Asthma Due to Der p 38 by Inhibiting Neutrophil Apoptosis

Geunyeong Kim, In Sik Kim

Objectives: Asthma is a prevalent chronic inflammatory lung disease characterized by symptoms such as wheezing, breathlessness, and coughing.Duchesnea indica (DI) or false strawberry exhibits a wide range of pharmacological effects, including anti-inflammatory and anti-cancer properties.This study aimed to determine whether DI extract …

kr (code pays fourni par la source)

Neuregulin-1 suppresses anti-apoptotic effect of Der p 38 on neutrophils by inhibition of cytokine secretion

Yujin Hong, Ji Hyeon Choi, Min Hwa Hong, Geunyeong Kim et autres

kr (code pays fourni par la source)

New approaches to immunotherapy in house dust mite allergy

In Sik Kim

Allergen immunotherapy (AIT) has developed over the last few decades and has emerged as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various modified HDM allergens have been improved for their efficacy. Moreover, clinical trials have …

kr (code pays fourni par la source)

Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis

Hyang Hwa Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong et autres

Atopic dermatitis (AD) is a chronic relapsing pruritic disease encompassing skin inflammation and barrier dysfunction. House dust mites are key allergens that augment the development of atopic dermatitis. We aimed to investigate the pathogenic mechanism of AD due to Der p 38, …

kr (code pays fourni par la source)

Der p 38 Is a Bidirectional Regulator of Eosinophils and Neutrophils in Allergy

Min Hwa Hong, Ayesha Kashif, Geunyeong Kim, Beom Seok Park et autres

Abstract The house dust mite is the most common cause of allergic diseases, and TLR4 acts as an overarching receptor for allergic responses. This study aimed to identify novel allergen binding to TLR4 in house dust mites and unveil its unique role …

kr, Éthiopie (code pays fourni par la source)

Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis

Ji Sun Ha, Hye-Rim Choi, In Sik Kim, Eun-A L Kim et autres

S100 calcium-binding protein A8 (S100A8), a danger-associated molecular pattern, has emerged as an important mediator of the pro-inflammatory response. Some S100 proteins play a prominent role in neuroinflammatory disorders and increase the secretion of pro-inflammatory cytokines in microglial cells. The aim of …

kr (code pays fourni par la source)

Metformin or α-Lipoic Acid Attenuate Inflammatory Response and NLRP3 Inflammasome in BV-2 Microglial Cells

Hye-Rim Choi, Ji Sun Ha, In Sik Kim, Seung-Ju Yang

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease that can be described by the occurrence of dementia due to a decline in cognitive function.The disease is characterized by the formation of extracellular and intracellular amyloid plaques.Amyloid beta (Aβ) is a …

kr (code pays fourni par la source)

Der p 38 is a bidirectional regulator of eosinophils and neutrophils in allergy

Min Hwa Hong, Ayesha Kashif, Geunyeong Kim, Beom Seok Park et autres

Background: The house dust mite (HDM) is the most common cause of allergic diseases, and TLR4 acts as an overarching receptor for allergic responses. This study aimed to identify novel allergen binding to TLR4 in HDMs and unveil its unique role in …

kr, Éthiopie (code pays fourni par la source)