Ying Du

Human cerebral organoids reveal PFOA-induced axonal injury as a conserved mechanism of neurodevelopmental disruption

Wei-Ran Chen, Yun Huang, Wei Zhou, Jian Yang et autres

Perfluorooctanoic acid (PFOA), a persistent environmental contaminant of growing public health concern, has been epidemiologically linked to neurodevelopmental deficits, yet its direct pathogenic mechanisms remain poorly defined. Our study addresses this critical gap by employing a unique cross-species framework that integrates zebrafish …

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Effects of finger acupressure combined with lower limb rehabilitation training machine on stroke recovery

Xiaoxue Liu, Feng Zhang, Yanhong Li, J. L. Zhao et autres

Background: Stroke is a common acute cerebrovascular disease, and rehabilitation therapy plays a crucial role in the recovery of stroke patients. Methods: In this retrospective study, we first enrolled 80 stroke patients. These participants were then randomly divided into two groups: the …

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Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor

Yucui Jiang, Yingxin Zong, Ying Du, Miaomiao Zhang et autres

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[Mechanism of ring finger protein 11 regulating Akt signaling pathway to promote osteogenic differentiation of bone marrow mesenchymal stem cells].

Wen Deng, Ting Long, Ying Du

OBJECTIVE: To investigate the role and regulatory mechanism of ring finger protein 11 (RNF11) on Akt signaling pathway in the process of osteogenesis of bone marrow mesenchymal stem cells (BMSCs) to provide ideas for further clarifying its osteogenesis mechanism and its use …

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Exosomes derived from LPS-stimulated human thymic mesenchymal stromal cells enhance inflammation via thrombospondin-1

Qianru Li, Jing Li, Lei Sun, Yun Sun et autres

Inflammatory response mediated by immune cells is either directly or indirectly regulated by mesenchymal stromal cells (MSCs). Accumulating evidence suggests that thrombospondin-1 (TSP-1) is highly expressed in response to inflammation. In this work, we isolated and identified human thymic mesenchymal stromal cells …

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Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report

Ran Du, Feng Jiang, Zhengyan Wang, Yanqing Kang et autres

BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) of the endometrium is an uncommon and highly aggressive tumor that has not been comprehensively characterized. We report a case of pure endometrial LCNEC and review the current literature of similar cases to raise awareness of …

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Identification of key gene modules and genes in colorectal cancer by co-expression analysis weighted gene co-expression network analysis

Peng Wang, Huaixin Zheng, Jiayu Zhang, Yashu Wang et autres

Colorectal cancer (CRC) has been one of the most common malignancies worldwide, which tends to get worse for the growth and aging of the population and westernized lifestyle. However, there is no effective treatment due to the complexity of its etiology. Hence, …

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Efficacy Analysis of Bronchoscopic Interventional Therapy for Benign Tracheal Stenosis by Combination of Intelligent Imaging Analysis System and Immunohistochemistry

Ying Du, Yunfeng Chen, Jincheng Huang

Objective: To assess the efficacy of bronchoscopic interventional therapy for benign tracheal stenosis by combination of intelligent imaging analysis system and immunohistochemistry. Methods: The therapeutic effect was evaluated by Computed Tomography (CT) image changes, and the effects of thermofrequency and glucocorticoids were …

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[Research progress of mast cell activation-related receptors and their functions].

Yucui Jiang, Fan Ye, Ying Du, Zongxiang Tang

Mast cells are widely distributed in various parts of the body, especially in the mucosal surface between the body and the external environment. Mast cell is one of the important immune cells and plays important roles in innate immunity, adaptive immunity and …

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Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

M. Li, J. Han, Yi Zhang, Jie Lv et autres

BACKGROUND AND PURPOSE: Low-density-lipoprotein-receptor-associated protein 4 (LRP4) autoantibodies have recently been detected in myasthenia gravis (MG), but little is known about the clinical characteristics associated with this serological type. In this study, the clinical features of Chinese patients with anti-LRP4 antibody-positive MG …

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Clinical characteristics of AChRAb and MuSKAb double seropositive myasthenia gravis patients

Mingqiang Li, Lu Ren, Yingna Zhang, Jie Lv et autres

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The overexpression of Fra1 disorders the inflammatory cytokine secretion by mTEC of myasthenia gravis thymus

Q.‐R. Li, Wenpeng Ni, Jinmeng Yang, Xiao Yan Xuan et autres

The thymus of a myasthenia gravis (MG) patient is often accompanied by and effected with follicular hyperplasia. Inflammatory cytokines in thymus induce the formation of germinal centres (GC). MG thymic inflammatory cytokines are predominantly secreted by stromal cells. Our previous studies revealed …

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