Efficacy Analysis of Bronchoscopic Interventional Therapy for Benign Tracheal Stenosis by Combination of Intelligent Imaging Analysis System and Immunohistochemistry

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Objective: To assess the efficacy of bronchoscopic interventional therapy for benign tracheal stenosis by combination of intelligent imaging analysis system and immunohistochemistry. Methods: The therapeutic effect was evaluated by Computed Tomography (CT) image changes, and the effects of thermofrequency and glucocorticoids were analyzed by animal experiments. Eighteen patients with benign tracheal stenosis who were enrolled in 2017.06–2019.06 were enrolled, and the thickness, diameter and lumen area of the most narrow tracheal tube before and after bronchoscopy and 1 month after bronchoscopy were measured using intelligent image analysis software. Thirty male SD rats were randomly divided into three groups (Radiofrequency group, Glucocorticoids+Radiofrequency group and control group). At the 5th, and 28th day the comparisons were made on the pathological changes of rats skin,the average optical density value of TGF-β1 and the collagen density after the damage by Radiofrequency, Glucocorticoids+Radiofrequency. Results: The thickness, diameter and lumen area of the wall before and after bronchoscopy are: 3.17 ± 1.01 mm versus 1.60 ± 0.23 mm; 3.61 ± 1.23 mm versus 9.04 ± 1.00 mm; 11.19 ± 5.32 versus 67.34 ± 13.80 mm2. The scar healing was observed in Radiofrequency group, but in the Glucocorticoids+Radiofrequency group the rats’ skin were healed incompletely. The results showed significant statistical differences among three groups on TGF-β1 comparisons: 988.41 ± 111.91, 730.19 ± 109.52 and 437.37 ± 60.48 (P < 0.05). The same results of comparisons on the collagen density showed: 96540.58 ± 29909.51, 43768.16 ± 6264.72 and 34521.15 ± 4636.19 (P < 0.05). Conclusions: After bronchoscopy intervention, the wall thickness of benign tracheal stenosis can be reduced, and the lumen diameter and area can be increased. The results can be analyzed using CT. Locally injected Betamethasone can alleviate the cicatricial tissue hyperblastosis induced by radiofrequency.

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