Süleyman Caner Karahan

Nilotinib attenuates NLRP3 inflammasome activation and GSDMD/NINJ1-mediated pyroptosis via modulation of NF-κB signaling and enhancement of BAG3-dependent aggrephagy and ESCRT-III-mediated plasma membrane repair in microglia

Mehmet Erdem, Şeniz Erdem, Süleyman Caner Karahan

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Estudio de los niveles de proteína básica de mielina (MBP) y albúmina modificada por isquemia (IMA) en sangre y líquido cefalorraquídeo, y su relación con el vasoespasmo, la evolución clínica y el pronóstico en pacientes con hemorragia subaracnoidea no traumática

Adil Ugur Yavuz, Ali Rıza Guvercin, Ali Samet Topsakal, Eda Altunbag Yavuz et autres

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Serum SCUBE1 and SCUBE2 Levels in Children with Immunoglobulin A Vasculitis: An Exploratory Study

Gülbahar KURT BAYIR, F. Merve Demir, Süleyman Caner Karahan, Mukaddes Kalyoncu

INTRODUCTION: SCUBE1 and SCUBE2 are vascular-associated proteins involved in endothelial processes. Although these molecules have been investigated in several vascular and inflammatory disorders, their potential involvement in pediatric immunoglobulin A vasculitis (IgAV) has not yet been elucidated. IgAV is the most common …

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Umbilical Coiling Index, Doppler Parameters, and Cord Blood Gas Analysis: Lack of Correlation in Uncomplicated Term Pregnancies

Zeynep Begum Celik, Gulseren Dinc, Süleyman Caner Karahan, Sumeyye Sura Ayan et autres

Background/Objectives: In this study, we aimed to evaluate whether neonatal ischemia-modified albumin (IMA) and umbilical venous cord blood gas parameters are associated with antenatal markers of fetal well-being, including the umbilical coiling index (UCI) and umbilical artery (UA) and middle cerebral artery …

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Research of the effects of myelin basic protein (MBP) and ischemia modified albumin (IMA) levels in blood and cerebrospinal fluid on vasospasm, clinical progress and outcome in patients with non-traumatic subarachnoid hemorrhage

Adil Ugur Yavuz, Ali Riza Guvercin, Ali Samet Topsakal, Eda Altunbag Yavuz et autres

BACKGROUND: Non-traumatic subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality, mainly due to secondary brain injury mechanisms such as cerebral vasospasm and delayed cerebral ischemia. Reliable biochemical biomarkers for monitoring disease progression and early outcome assessment remain limited. OBJECTIVE: To …

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Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells

Ömer Faruk Kalkan, Şeniz Erdem, Mehmet Erdem, Satinur Ateşer Kalkan et autres

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Increased Serum Signal Peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial Growth Factor Domain-Containing Protein-1 May Have a Role in the Pathophysiology of Late-Onset Fetal Growth Restriction

Gülseren Dinç, Süleyman Caner Karahan, Süleyman Güven

Background/Objective: Fetal growth restriction (FGR) is a condition in which the fetus fails to grow as expected for gestational age, and its growth is restricted. This study aimed to investigate the role of SCUBE-1, a new ischemia marker, in the diagnosis of …

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RELATIONSHIP OF NEURON SPECIFIC ENOLASE LEVELS IN SERUM AND CEREBRO SPINAL FLUID WITH COMPLICATIONS AND CLINICAL FOLLOW-UP IN PATIENTS WITH ACUTE BACTERIAL MENINGITIS

Şadan Hacısalihoğlu, Ahmet Alver, Murat Topbaş, Süleyman Caner Karahan et autres

Amaç: Bu çalışmadaki amacımız; bakteriyel menenjitli hastalarda serum c-reaktif protein ile beyin omurilik sıvısı ve kan nöron spesifik enolaz düzeylerinin ilişkisini araştırmaktır. Gereç ve Yöntemler: Bu çalışma Eylül 2000 ile Eylül 2001 tarihleri arasında akut bakteriyel menenjit tanısı konarak tedavi edilen 22 …

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The Role of TRAIL, IP-10 and MxA in Distinguishing Acute Community-acquired Viral and Bacterial Pneumonia in Children

Fırat Gündoğmuş, Zeynep Gökçe Gayretli Aydın, Süleyman Caner Karahan, Serap Özer Yaman

Acute paediatric community-acquired pneumonia (pedCAP) represents a significant burden on child health and highlights the need for accurate diagnostic tools. This study aimed to differentiate between acute community-acquired viral and bacterial pedCAP using TRAIL, IP-10, and MxA markers.The study a single-center prospective …

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Vascular Cell Adhesion Molecule-1 and Complement C3 involvement in Febrile Seizures in Children

Sevim Şahin, Serap Özer Yaman, Süleyman Caner Karahan, Mukaddes Kalyoncu

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The brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone mitigates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis and enhances the negative regulatory pathways of pyroptosis in microglia

Mehmet Erdem, Şeniz Erdem, Süleyman Caner Karahan, Ahmet Alver et autres

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Serum Calcium Levels, Erythrocyte Indices, and Associated Factors in Children with Febrile Seizures

Sevim Şahin, Nihal Yıldız, Gülnur Esenülkü, Pınar Özkan Kart et autres

Febrile seizures (FS) are the most common seizures in childhood. In most studies, iron deficiency was associated with FS, whereas serum calcium (Ca) levels were contradictory. This study evaluated the relationships of erythrocyte indices, serum Ca levels, and related factors among children …

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