A. Zeller

Dynamic Regulation of Collagens, Proteases, Their Inhibitors, and Cell Death in Experimental Asthma in Mice

Marlena Tynecka, Agnieszka Tarasik, Bartosz Hanczaruk, Adrian Janucik et autres

Asthma is a complex airway disorder driven by diverse immunological pathways. While type 2 (T2)-mediated inflammation is well characterized, the mechanisms underlying T2-low (also referred to as mixed inflammatory phenotype) or non-T2-mediated asthma, often associated with Th1/Th17-driven immune responses and high pulmonary …

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Adenosine‐to‐inosine editing of miR ‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Magdalena Niemira, Anna Skwarska, Karolina Chwiałkowska, Gabriela Sokołowska et autres

Deamination of adenosine to inosine (A-to-I) in double-stranded microRNAs (miRNAs) has been demonstrated to affect their function as suppressors or oncogenes in various cancers. Nevertheless, the functional impact of miRNA editing in high-grade serous ovarian cancer (HGSOC) remains largely unexplored. Here, we …

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Repurposing of PI3K inhibitors for high-grade serous ovarian cancer: A novel competing endogenous network analysis-based approach

Anna Erol, Karolina Chwiałkowska, A. Zeller, Anna Skwarska et autres

INTRODUCTION: The average survival time for High-Grade Serous Ovarian Cancer (HGSOC) is around 3.4 years post-diagnosis. The treatment options are limited, especially for relapsed patients, resistant to standard treatment. Therefore, novel drug candidates are needed. OBJECTIVE: We propose a novel approach for …

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Insights into RNA ‐mediated pathology in new mouse models of Huntington's disease

M. Woźna, Magdalena Jazurek, Łukasz Przybył, Dorota Wronka et autres

Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting from the expansion of CAG repeats located in the ORF of the huntingtin gene (HTT). The extent to which mutant mRNA-driven disruptions contribute to HD pathogenesis, particularly in comparison to the dominant …

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B008 Mutant RNA contributes to neuropathology in new mouse models of Huntington’s disease

M. Woźna, Magdalena Jazurek, Łukasz Przybył, Dorota Wronka et autres

Background Huntington’s disease results from the expansion of CAG repeats in the huntingtin gene (HTT). The extent to which mutant mRNA-driven disruptions contribute to neurodegeneration in HD is still a subject of debate, particularly in comparison to the dominant mechanisms related to …

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Mesenchymal stromal cells effectively limit house dust mite extract‐induced mixed granulocytic lung inflammation

Marlena Tynecka, Adrian Janucik, Agnieszka Tarasik, Arkadiusz Żbikowski et autres

Mesenchymal stromal cells (MSCs, also known as mesenchymal stem cells) have gained considerable interest due to their immunosuppressive properties and regenerative potential. In the vast majority of published papers, the beneficial effects of MSCs in asthma have been confirmed in experimental eosinophilic …

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Circulating serum miR-362-3p and miR-6721-5p as potential biomarkers for classification patients with adult-type diffuse glioma

Magdalena Niemira, Agnieszka Bielska, Karolina Chwiałkowska, Justyna Raczkowska et autres

According to the fifth edition of the WHO Classification of Tumours of the Central Nervous System (CNS) published in 2021, grade 4 gliomas classification includes IDH-mutant astrocytomas and wild-type IDH glioblastomas. Unfortunately, despite precision oncology development, the prognosis for patients with grade …

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High tumour-infiltrating lymphocytes correlate with distinct gene expression profile and favourable survival in single hormone receptor-positive breast cancer

Aleksandra Ciarka, Michał Kunc, Marta Popęda, Aleksandra Łacko et autres

Introduction: This study aimed to evaluate the impact of tumour-infiltrating lymphocytes (TILs) on the expression of immune-related genes and prognosis in single hormone receptor-positive breast cancer. Material and methods: Tumour-infiltrating lymphocytes were analysed according to the guidelines of the International TILs Working …

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Identification of serum miR-1246 and miR-150-5p as novel diagnostic biomarkers for high-grade serous ovarian cancer

Magdalena Niemira, Anna Erol, Agnieszka Bielska, A. Zeller et autres

Epithelial ovarian cancer (EOC) is one of the leading cancers in women, with high-grade serous ovarian cancer (HGSOC) being the most common and lethal subtype of this disease. A vast majority of HGSOC are diagnosed at the late stage of the disease …

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Development of an extensive workflow for comprehensive clinical pharmacogenomic profiling: lessons from a pilot study on 100 whole exome sequencing data

Alireza Tafazoli, Maaike van der Lee, Jesse J. Swen, A. Zeller et autres

This pilot study is aimed at implementing an approach for comprehensive clinical pharmacogenomics (PGx) profiling. Fifty patients with cardiovascular diseases and 50 healthy individuals underwent whole-exome sequencing. Data on 1800 PGx genes were extracted and analyzed through deep filtration separately. Theoretical drug …

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The NSCL cyclotron gas stopper – Entering commissioning

S. Schwarz, G. Bollen, S. Chouhan, J.J. Das et autres

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Cooling and Operation of the MSU Cyclotron Gas-Stopper Magnet

M. A. Green, C. Magsig, G. Bollen, S. Chouhan et autres

The two coils of the cyclotron gas-stopper magnet at Michigan State University (MSU) were each cooled down and filled with liquid helium made from 300-K gas separately using three PT415 coolers in the fall of 2014. The magnet was first powered in …

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