Lu Lm

A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium

Xi Zhang, Anqun Chen, Linli Lv, Liang Ma et autres

Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and is an independent risk factor for kidney and systemic degenerative diseases. On 16 May 2025, the Aging Biomarker Consortium convened an expert consensus meeting in Shanghai, …

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A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus

Yuren Shi, Guangxu Zhang, Siyu Lin, Mingda Hu et autres

ABSTRACT Oropouche virus (OROV) is reemerging in the Americas, along with a growing threat to global public health. Recent outbreaks have witnessed the first reported fatalities, vertical transmissions, and intercontinental importations of OROV, underscoring its expanding risk. Despite this, no vaccines or …

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[Angiotensin II participates in stress-induced high blood pressure via stimulating hypothalamic vasopressin synthesis and release].

Lu Lm, J Wang

Experiments were carried out in male Sprague-Dawley rats. The animals were randomly divided into three groups: control, stressed and stress + captopril. Stress stimulations were composed of repeated electric foot-shock combined with noise, twice one day (2 h each session) for 15 …

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[Changes in vasopressin V1 receptor mRNA level in rats with high blood pressure induced by chronic stress].

Lu Lm, J Wang

Using reverse transcription polymerase chain reaction (RT-PCR) combined with Southern blotting hybridization technique, the AVP V1 receptor mRNA was found to be widely distributed in central neuronal system and other tissues of rats, such as cerebral cortex, hypothalamus, medulla, liver and kidney. …

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[Effect of stressful stimulations on hypothalamic vasopressin mRNA level of rats].

Lu Lm, Li Hy, R Wang

Experiments were carried out in stressful foot shock and noise stimulated male Sprague Dawlay rats. 3'-end digoxigenin-labeled 26 mer oligonucliotide probe was used to detect the vasopressin (AVP) mRNA in hypothalamic tissues. Dot blotting technique was used in the assessment of AVP …

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[Effects of gonadal steroid hormones on hypothalamic vasopressin mRNA level in male and female rats].

Dai Wj, Lu Lm

Experiments were carried out in 10-11-week old gonadectomized male and female Sprague-Dawley rats. Dot-blot analysis and 3'-end digoxigenin-labeled 26 meroligonucleotide probe was used in detecting the mRNA level hypothalamic vasopressin (AVP). The basal hypothalamic AVP-mRNA level in the sham-operated intact males was …

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Production of tumor necrosis factor in germfree mice.

Lu Lm