Mingda Hu

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization

X T Wang, Guanying Zhang, Mingda Hu, Jin Han et autres

Abstract Therapeutic antibodies are challenged by rapidly evolving pathogens that exploit glycosylation to shield epitopes. SARS-CoV-2 JN.1 exemplifies this, escaping antibodies through the N354-linked glycan. However, targeting glycosylated epitopes remains vacant, as scarce and heterogeneous glycan structures render existing approaches ineffective. Here, …

cn (code pays fourni par la source)

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization

X T Wang, Guanying Zhang, Mingda Hu, Jin Han et autres

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization The Antibody Evolution Nexus with Causal-Driven Simulation (AENCS) is a white-box computational-experimental framework for antibody engineering. By integrating physics-based simulation with causal inference, AENCS addresses a long-vacant frontier: …

cn (code pays fourni par la source)

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization

X T Wang, Guanying Zhang, Mingda Hu, Jin Han et autres

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization The Antibody Evolution Nexus with Causal-Driven Simulation (AENCS) is a white-box computational-experimental framework for antibody engineering. By integrating physics-based simulation with causal inference, AENCS addresses a long-vacant frontier: …

cn (code pays fourni par la source)

A computational pipeline to discover potential cross-reactive antibodies: a case study on coronavirus

Li Ye, Mingda Hu, Yuxuan Wang, Zihao Li et autres

Introduction Cross-reactive antibody (crAb), which recognizes conserved viral epitopes across diverse strains, has emerged as powerful tools for diagnostics, therapeutic targeting, and pandemic preparedness. Yet conventional crAb discovery primarily relies on hybridoma technology and phage display which are time-consuming and labor-intensive. Methods …

cn (code pays fourni par la source)

A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus

Yuren Shi, Guangxu Zhang, Siyu Lin, Mingda Hu et autres

ABSTRACT Oropouche virus (OROV) is reemerging in the Americas, along with a growing threat to global public health. Recent outbreaks have witnessed the first reported fatalities, vertical transmissions, and intercontinental importations of OROV, underscoring its expanding risk. Despite this, no vaccines or …

cn (code pays fourni par la source)

A highly potent, stable, and safe dePEGylated lipopeptide against Nipah virus and related henipaviruses

Yuanzhou Wang, Cong Wang, Jie Zhou, Guangxu Zhang et autres

Nipah virus (NiV) poses a significant threat owing to its high mortality and the lack of approved therapeutics. Targeting the conserved heptad repeat 1 (HR1) domain of the viral fusion (F) protein constitutes a promising antiviral strategy. Also, lipopeptides derived from the …

cn (code pays fourni par la source)

Predicting antibiotic resistance genes and bacterial phenotypes based on protein language models

Boqian Wang, Renjie Meng, Zong Li, Mingda Hu et autres

Introduction: Antibiotic resistance is emerging as a critical global public health threat. The precise prediction of bacterial antibiotic resistance genes (ARGs) and phenotypes is essential to understand resistance mechanisms and guide clinical antibiotic use. Although high-throughput DNA sequencing provides a foundation for …

cn (code pays fourni par la source)

Molecular epidemiology and genomic insights into Enterobacter cloacae complex co-harbouring blaKPC and mcr: Implications for resistance gene transmission

Boqian Wang, Yaqing He, Kexin Li, Guifang Hu et autres

cn, cz (code pays fourni par la source)

Flu-CNN: identifying host specificity of Influenza A virus using convolutional networks

Mingda Hu, Nan Luo, Boqian Wang, Renjie Meng et autres

Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species that can be infected. However, these barriers are not absolute, and occasionally, cross-species transmission …

cz, cn (code pays fourni par la source)

Genetic characteristics of rotavirus a in Shenzhen and Zhuhai, China, 2020–2023

Mingda Hu, Yixiong Lin, Rui Zhang, Xin Wang et autres

BACKGROUND: Rotavirus A group (RVA) is a leading cause of viral diarrhea, posing a substantial economic and public health burden. Compared to other enteric viruses, RVA possesses diverse genetic mechanisms, making it more challenging to control and prevent. Moreover, surveillance and evolutionary …

cn, cz (code pays fourni par la source)

Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022

Xin Wang, Wanqiu Liu, Mingda Hu, Hui Ma et autres

Introduction: Norovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics …

cn, cz (code pays fourni par la source)

Report of two coinfections of human adenovirus and sapovirus in patients with acute gastroenteritis from China

Xin Wang, Yaqing He, Mingda Hu, Wanqiu Liu et autres

cn, hk (code pays fourni par la source)