Innovative Therapy with Stem Cell-Derived Extracellular Vesicles on Cardiac Hypertrophy in an Animal Model of Atherosclerosis; Elucidation of the Molecular Mechanisms Involved in the Repair Process
Rattachement africain : ro. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
(1) Background: The present study investigated the effects of extracellular vesicles (EVs), derived from adipose tissue stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMMSCs), on atherosclerosis-associated cardiac hypertrophy. (2) Methodology: The experiments were performed on hamsters divided into the following groups: control (C) fed with a standard diet; hypertensive–hyperlipidemic (HH) generated by combining a diet enriched with 3% cholesterol, 15% butter, and by gavage with 8% NaCl on a daily basis; HH groups injected with EVs (ADSCs) or EVs (BMMSCs), either transfected with Smad2/3 siRNAs or not (HH-EVs (ADSCs), HH-EVs (BMMSCs), HH-EVs (ADSCs) + Smad2/3siRNA, HH-EVs (BMMSCs) + Smad2/3siRNA); and HH group injected with Smad2/3 siRNAs (HH-Smad2/3siRNA). (3) Results: In comparison with the HH group, the findings demonstrated that treatment using EVs (ADSCs or BMMSCs), either with or without Smad2/3 siRNAs, resulted in several significant improvements in the following aspects: the plasma levels of cholesterol, LDL, triglycerides, TGF-β1, and Ang II were decreased; the left ventricular structure and function were recovered; inflammatory markers, ROS, COL1A, α-SMA, Cx43, MIF, ANF, and M1/M2 macrophages, were reduced; the level of key protein NF-κB p50 was diminished. (4) Conclusions: These findings underscore the therapeutic potential of mesenchymal stem cell-derived EVs in atherosclerosis-associated cardiac hypertrophy.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Innovative Therapy with Stem Cell-Derived Extracellular Vesicles on Cardiac Hypertrophy in an Animal Model of Atherosclerosis; Elucidation of the Molecular Mechanisms Involved in the Repair Process
- Date Crossref
- 07/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Romanian Academy Department of Pathophysiology and Cellular Pharmacology pays non établi dans la noticeInstitution
-
Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara pays non établi dans la noticeÉtablissement de santé
-
Victor Babeș University of Medicine and Pharmacy Timișoara pays non établi dans la noticeUniversité ou école supérieure
-
Clinical Emergency County Hospital “Pius Brinzeu” Timisoara Center for Gene and Cellular Therapies in the Treatment of Cancer Timisoara-OncoGen pays non établi dans la noticeÉtablissement de santé
-
“Victor Babes” University of Medicine and Pharmacy Department of Functional Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Clinical Emergency County Hospital "Pius Brinzeu" Timisoara Center for Gene and Cellular Therapies in the Treatment of Cancer Timisoara-OncoGen pays non établi dans la noticeÉtablissement de santé
-
"Victor Babes" University of Medicine and Pharmacy Department of Functional Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Pathophysiology and Cellular Pharmacology — Romanian Academy, Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara et Victor Babeș University of Medicine and Pharmacy Timișoara, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.