Robert Cheek

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

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Autoantibodies in chronic graft versus host result from cognate T-B interactions

Philip L. Cohen, Robert Cheek, Robert A. Eisenberg, Suzanne C. Morris

A chronic graft-versus-host reaction (GVH) induced in nonautoimmune mice causes a syndrome that closely resembles SLE. In this model, donor T cells react against incompatible host Ia structures and generate excessive help, which activates a subpopulation of self-reactive B cells. We have …

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Performance of a biomarker panel to identify malignancy within a pelvic mass population

L. Chen, Howard D. Homesley, Dennis R. Scribner, Guilherme Cantuaria et autres

5566 Background: We previously reported the performance of biomarker combinations that displayed utility in identifying ovarian cancer from normal sera and in monitoring for disease recurrence. In this study, we evaluated the performance of a subset of these markers in differentiating ovarian …

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Abstract #1579: Characterization of monoclonal antibodies to glycodelin showing clinical utility in the identification of ovarian cancer

Jeffrey P. Baker, Robert Cheek, John Groelke, Qin He et autres

Ovarian cancer, the fourth leading cause of cancer death, is diagnosed in more than 22,000 women in the U.S each year. The only established biomarker for ovarian cancer is CA125, which shows low sensitivity for detecting early stage ovarian cancer. The prognosis …

Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence

Laura J. Havrilesky, Clark M. Whitehead, Jennifer M. Rubatt, Robert Cheek et autres

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The molecular characterization of two novel antibodies to HE4 and their utility in detecting early stage ovarian cancer

Robert Cheek, Lorraine King, Malena Sansbury, Qin He et autres

2669 The 5 year survival rate for epithelial ovarian cancer (EOC) depends greatly on the stage of the disease at the time of diagnosis; increased survival is associated with early detection (i.e. Stage 1 or 2). However, the vast majority of ovarian …

Immunological and Pathological Consequences of Mutations in both Fas and Fas Ligand

Jory P. Weintraub, Virginia Godfrey, P A Wolthusen, Robert Cheek et autres

The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low …

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B cell genotype determines the fine specificity of autoantibody in lpr mice

V.N. Kakkanaiah, Eric S. Sobel, Glen C. MacDonald, Robert Cheek et autres

Anti-Sm Abs are specific markers of human systemic lupus erythematosus (SLE) and of murine models of this disease. In humans, anti-Sm Abs are mostly IgG1, and in MRL/lpr mice, IgG2a; both are T-dependent isotypes. Other lpr strains, such as B6/lpr, do not …

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MHC genes modify systemic autoimmune disease. The role of the I-E locus

E A Creech, Danièle Nakul‐Aquaronne, Elizabeth A. Reap, Robert Cheek et autres

The MHC exerts an important influence on systemic autoimmune disease. In C57BL/6-lpr/lpr (B6/lpr) mice, substitution of the H-2d instead of the H-2b MHC haplotype results in a global reduction in autoantibody levels. Since H-2d expresses both I-A and I-E, while H-2b expresses …

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T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.

Eric S. Sobel, V.N. Kakkanaiah, M Kakkanaiah, Robert Cheek et autres

A central question in autoimmunity is the mechanism of T cell help for autoantibody production. For responses to exogenous Ag, T-B collaboration is restricted by MHC class II molecules. To determine whether T cell help that leads to autoantibodies in murine SLE …

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Proliferating cell nuclear antigen (PCNA): predictor of pathologic response of advanced rectal cancer to preoperative irradiation

Christopher G. Willett, Robert Cheek, Gretchen Warland, Paul C. Shellito et autres

Implementation of capillary blood glucose monitoring in a teaching hospital and determination of program requirements to maintain quality testing

Kent Lewandrowski, Robert Cheek, David M. Nathan, John E. Godine et autres

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