Guangsheng Zhu

RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness

Renwang Liu, Mingbiao Li, Zixuan Hu, Shen Yang et autres

Maintenance of cancer stemness drives lung cancer recurrence, metastasis, and refractoriness. Limited drug efficacy against existing stemness mechanisms suggests the existence of undiscovered complex regulatory networks. Previously, we found that RAD51AP1 is positively associated with lung cancer stemness; here, we showed that …

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P2RY13-Negative Tumor-Associated Macrophages Promote NETosis and Are Associated with Poor Prognosis Across Multiple Cancers

Shen Yang, Guangsheng Zhu, Zixuan Hu, Mingbiao Li et autres

Background: Neutrophil extracellular traps (NETs) promote tumor progression and immune evasion across multiple cancers. However, the mechanisms governing NET formation (NETosis) within the tumor immune microenvironment remain incompletely understood. Low P2RY13 expression is associated with the pro-tumor activity of neutrophils in lung …

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Dissecting tumor heterogeneity in colorectal cancer: uncovering the role of BCL2L1+ cells through single-cell analysis

Guangsheng Zhu, Ya Liu, Yunxuan Shi, Nuan Qian et autres

Background Colorectal cancer (CRC) ranks among the most prevalent gastrointestinal malignancies with liver metastasis being the primary cause of CRC-related death. Although surgical and chemotherapeutic interventions continue to improve, patients with hepatic metastases frequently experience recurrence and limited treatment benefits. Liver metastasis …

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GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma

Guangsheng Zhu, Xuan-guang Li, Pei-jun Cao, Yuxuan Wang et autres

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Clipping Posteriorly Directed Posterior Communicating Artery Aneurysms Using the Anterior Temporal Approach

Guangsheng Zhu, Bin Chen, Xiaoling Jiang, S Li et autres

OBJECTIVE: To investigate the advantages and essential technical aspects of the anterior temporal approach (ATA) in clipping the posteriorly directed posterior communicating artery (PCOM) aneurysms. METHODS: Anatomical dissections using the ATA were performed on 2 cadaveric heads (4 sides) to expose PCOM …

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Metal Node Control of Coordinatively Unsaturated Sites in Heterobimetallic MOFs for Stable and High Ammonia Adsorption

Yajie Shu, Danni Wang, Hao Gu, Guangsheng Zhu et autres

The escalating demand for ammonia (NH 3 ) as an energy vector and chemical feedstock, coupled with its toxic and corrosive nature, has raised serious environmental and health concerns due to widespread emissions. The development of sorbents with both high capacity and …

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CD40LG Downregulation in Lung Adenocarcinoma: A Prognostic Biomarker Linked to Immune Cell Infiltration and Survival Outcomes

Peng Tang, Ruihao Zhang, Yuqi Zhang, Ao Yuan et autres

Background: Lung adenocarcinoma (LUAD) continues to pose a major challenge in cancer treatment, characterized by low survival rates, particularly in metastatic instances.Although immunotherapy has become a common approach for treating LUAD, its success rate is merely 20%, hindered by the absence of …

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Genome-wide CRISPR-Cas9 screening identifies ITGA8 responsible for abivertinib sensitivity in lung adenocarcinoma

Xuan-guang Li, Guangsheng Zhu, Hua Huang, Yuhao Chen et autres

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Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review

Sidikjan Ibrahim, Amina Maimaitiaili, Guangsheng Zhu, Shengwei Ye

BACKGROUND: Regional lymph nodes that are fixed and fused into clusters or those exhibiting metastases outside the regional lymph nodes are generally classified as stage IV (M1) or unresectable. Patients with such nodes almost always need pre-operative treatment so that they can …

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L3MBTL1, a polycomb protein, promotes Osimertinib acquired resistance through epigenetic regulation of DNA damage response in lung adenocarcinoma

Zihe Zhang, Li Y, Ruifeng Shi, Chaoyi Jia et autres

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (EGFR-TKI) approved for patients with EGFR T790M resistance mutations as first- or second-line treatment of EGFR-positive patients. Resistance to Osimertinib will inevitably develop, and the underlying mechanisms are largely unknown. …

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Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells

Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang et autres

Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) remodeling and fibroblast activity, play pivotal roles in cancer progression …

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Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers

Hua Huang, Lianchun Su, Ruihao Zhang, Di Wu et autres

The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive pan-cancer analysis, complemented by experimental validation, to explore the potential of Nicotinamide N-methyltransferase (NNMT) as a promising therapeutic strategy for human cancers. By …

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