Shalini Adiga

Protective effects of Bacopa monnieri against cisplatin-induced hepatorenal toxicity in rats: biochemical, oxidative stress, histopathological, and Kidney Injury Molecule-1–based evidence

S. Sahana, Shivaprakash Gangachannaiah, Ravindra Maradi, K Venkata Krishna Rao et autres

Background and Aim: Cisplatin, a platinum-based chemotherapeutic agent, is widely employed in the treatment of various malignancies. However, its clinical utility is restricted by dose-limiting hepatorenal toxicities, primarily driven by oxidative stress, inflammation, and direct cytotoxicity. The present in vivo study was …

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Bioinformatics tool in Identification of the Structural and Functional Impact Of ACE Isoform 1 precursor gene.

Dinker Pai, Usha Sachidananda Adiga, Shalini Adiga, D Chaitra et autres

Background: The genetic variations in human genome causes considerable in the phenotype which is influenced by single nucleotide polymorphism. It is very challenging to determine which SNP in a candidate gene is responsible for a given phenotype, and requires testing hundreds or …

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Evaluation of protective effects of Bacopa monnieri in Doxorubicin induced Testicular toxicity in rats

K Ankitha, Shivani Singh, Reena Sherin Parveen, Shalini Adiga et autres

Background Doxorubicin is widely used as chemotherapeutic agent in many cancers along with other anticancer drugs. However, its use is hampered by its adverse effects. The present study aimed to evaluate the protective effect of Bacopa monnieri in ameliorating Doxorubicin(Dox) induced testicular …

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Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota

Mushraf Syed, Kiran Chawla, Fayaz SM, Jesil Mathew Aranjani et autres

BACKGROUND: Maintaining gut microbial homeostasis is crucial for human health, as imbalances in the gut microbiota (GM) can lead to various diseases, including metabolic syndrome (MS), exacerbated by the use of antipsychotic medications such as olanzapine (OLZ). Understanding the role of the …

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Comprehensive Educational Needs Assessment Plan for Non-Muscle Invasive Bladder Cancer (NMIBC) Patient Care and Treatment among Relevant Healthcare Professionals

Shalini Adiga, a b, J. Brahmaia

The primary objective of this study is to conduct a comprehensive educational needs assessment in the realm of non-muscle invasive bladder cancer (NMIBC).This assessment aims to identify gaps in knowledge, understanding, and patient care practices among healthcare professionals, focusing particularly on the …

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Empagliflozin modulates seizure activity and oxidative stress in rats with epilepsy

Neha Holla, Shalini Adiga, Meena Kumari, Mohandas Rao Kapettu Gadahad

Drug-resistant epilepsy, a commonly devastating condition, affects more than 50 million people globally. Type 2 diabetes mellitus (T2DM) is associated with an increased risk of neurological disorders, and a potential association between epilepsy and subsequent T2DM has emerged. Inhibiting sodium-glucose linked transporters …

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Serum SIRT1 Levels and Genetic Variants in Diabetic Nephropathy: Insights from a Cross-sectional study

Dinker Pai, Shalini Adiga, Gopalakrishnan Suresh, Usha Sachidananda Adiga et autres

The aim of the study was to compare sirtuin 1 serum levels in non-insulin dependent diabetics and diabetic nephropathy patients, and evaluate the pattern of polymorphism of SIRT 1 gene in these patients, and find the relation between polymorphism of SIRT1 gene …

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Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy

Shivakumar K Reddy, Abhijna R Ballal, S Shailaja, Raviraja Neelavar Seetharam et autres

Diabetic retinopathy (DR) is associated with retinal neovascularization, hard exudates, inflammation, oxidative stress and cell death, leading to vision loss.Anti-vascular endothelial growth factor (Anti-VEGF) therapy through repeated intravitreal injections is an established treatment for reducing VEGF levels in the retina for inhibiting …

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Dose-response relationship of photobiomodulation therapy and oxidative stress markers in healing dynamics of diabetic neuropathic ulcers in Wistar rats

Gagana Karkada, Arun G. Maiya, Praveen Ravindra Arany, Mohandas Rao KG et autres

Abstract Purpose: Diabetic foot ulcers are reported to be the most expensive complications of diabetes, with high morbidity and mortality rates. If the necessary care is not provided for the wound to heal, the individual may end up amputating the affected feet. …

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Dose–Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers—An in vivo Study

Gagana Karkada, Arun Gundmi Maiya, Praveen Ravindra Arany, Mohandas Rao KG et autres

Abstract Individuals with diabetic foot ulcers have overlapped the inflammatory, proliferative and remodeling phase, making the tissue vulnerable to delayed healing responses. We aimed to establish the dose–response relationship of photobiomodulation therapy of different doses and matrix metalloproteinases in the healing dynamics …

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Utilization of Indian diabetes risk score (IDRS) in steroid-induced diabetes

Nandakrishna Bolanthakodi, Avinash Holla, Sudha Vidyasagar, Bairy Laxminarayan et autres

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Effect of Photobiomodulation Therapy on Oxidative Stress Markers in Healing Dynamics of Diabetic Neuropathic Wounds in Wistar Rats

Gagana Karkada, Arun G. Maiya, Praveen Ravindra Arany, Mohandas Rao KG et autres

Abstract Background Prolonged and overlapping phases of wound healing in diabetes are mainly due to the redox imbalance resulting in the chronicity of the wound. Photobiomodulation therapy works on the principle of absorption of photon energy and its transduction into a biological …

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