Atsushi Umemura

Clioquinol induces mitochondrial toxicity in SH ‐ SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin‐like GTPase

Masato Katsuyama, Noriaki Arakawa, Takeshi Yaoi, En Kimura et autres

Clioquinol has been thought of as the causative drug of subacute myelo-optic neuropathy (SMON). The underlying mechanisms of clioquinol toxicity, however, have not been elucidated in detail. Here, we revealed that clioquinol (20 μm) suppressed the expression of SCO1 and SCO2 copper …

jp (code pays fourni par la source)

Author response for "Clioquinol induces mitochondrial toxicity in SH ‐ SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin‐like GTPase "

Masato Katsuyama, Noriaki Arakawa, Takeshi Yaoi, En Kimura et autres

Hepatocyte-specific GDF15 overexpression improves high-fat diet-induced obesity and hepatic steatosis in mice via hepatic FGF21 induction

Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano et autres

GDF15 and FGF21, stress-responsive cytokines primarily secreted from the liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the interaction between GDF15 and FGF21 remains unclear. We examined the effects of hepatocyte-specific GDF15 or FGF21 overexpression in high-fat …

jp (code pays fourni par la source)

Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning

Munenori Kawai, Akihisa Fukuda, Ryo Otomo, S. Obata et autres

BACKGROUND: Pancreatic cancer is often diagnosed at advanced stages, and early-stage diagnosis of pancreatic cancer is difficult because of nonspecific symptoms and lack of available biomarkers. METHODS: We performed comprehensive serum miRNA sequencing of 212 pancreatic cancer patient samples from 14 hospitals …

jp (code pays fourni par la source)

Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation

Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto et autres

Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that several proteasome …

jp (code pays fourni par la source)

Carfilzomib Shows Therapeutic Potential for Reduction of Liver Fibrosis by Targeting Hepatic Stellate Cell Activation

Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Kazumi Iwata et autres

jp (code pays fourni par la source)

Safety/efficacy of atezolizumab + bevacizumab during anti‐platelet/anticoagulation therapy in unresectable hepatocellular carcinoma

Michihisa Moriguchi, Keiichiro Okuda, Go Horiguchi, Seita Kataoka et autres

BACKGROUND AND AIMS: This study aimed to determine the safety and efficacy of atezolizumab + bevacizumab therapy in hepatocellular carcinoma patients receiving anti-platelet agents or anticoagulants. METHODS: Patients were divided into those using (IM out) and those not using (IM in) anti-platelet …

jp, us (code pays fourni par la source)

Hepatocyte-specific GDF15 overexpression improves high-fat diet-induced obesity and hepatic steatosis in mice via hepatic FGF21 induction

Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano et autres

Abstract GDF15 and FGF21, stress-responsive cytokines primarily secreted from liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the interaction between GDF15 and FGF21 remains unclear. We examined the effect of the hepatocyte-specific GDF15 or FGF21 overexpression in …

jp (code pays fourni par la source)

Inter-individual variations in circadian misalignment-induced NAFLD pathophysiology in mice

Nobuya Koike, Yasuhiro M. Umemura, Hitoshi Inokawa, Isao T. Tokuda et autres

Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine …

jp, us (code pays fourni par la source)

Editorial: Impacts of drug-induced oxidative stress

Atsushi Umemura

Impacts of drug-induced oxidative stress

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Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease

Kanji Yamaguchi, Yuya Seko, Takamitsu Sakai, Satomi Kitano et autres

Abstract Chronic liver disease includes nonalcoholic fatty liver disease, progresses from steatosis and hepatitis to fibrosis and cirrhosis, with hemodynamic changes in portal blood flow. This study aimed to compare portal vein hemodynamics with liver stiffness (LS) and steatosis and included 28 …

jp (code pays fourni par la source)

Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?

Ruolei Wang, Lirong Liang, Misaki Matsumoto, Kazumi Iwata et autres

The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress and ROS, which play a central role in regulating cell and tissue physiology and pathology. Contingent upon concentration, ROS influence cancer development in contradictory ways, either stimulating cancer survival …

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