Matthew M. Cooper

Early Mucosal Type II Interferon Limits SARS-CoV-2 Replication in Humans

Alexander Viloria Winnett, Alexandra Tabachnikova, Jonathan Chen, Kerrie Greene et autres

ABSTRACT COVID-19 vaccines markedly reduce disease severity, but their ability to block infection and transmission remains limited and variable. 1 A better understanding of early mucosal immune programs that constrain viral replication at susceptible upper respiratory sites is needed to develop more …

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Is RNA the Rosetta Stone for organ preservation?

Matthew M. Cooper

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The Evolution of Commercial Negative Pressure Wound Therapy Systems over the Past Three Decades

Cynthia Miller-Mikolajczyk, Karen Beach, Ronald P. Silverman, Matthew M. Cooper

Significance: Since the introduction of the first commercial negative pressure wound therapy (NPWT) system nearly three decades ago, several key technological innovations have led to the wide adoption of the therapy. This is a review of the history and innovation of commercial …

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The role community‐based healthcare providers play in managing hard‐to‐heal wounds

Dimitri Beeckman, Matthew M. Cooper, Emily Greenstein, Patricia Idensohn et autres

It is common for community-based healthcare providers (CHPs)-many of whom have not received specialised training in wound care-to deliver initial and ongoing management for various wound types and diverse populations. Wounds in any setting can rapidly transition to a stalled, hard-to-heal wound …

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Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

Alexander Viloria Winnett, Michael K. Porter, Anna E. Romano, Emily S. Savela et autres

Our findings suggest that collecting saliva and nasal swab specimens in the morning immediately after waking yields higher SARS-CoV-2 viral loads than collection later in the day. The higher viral loads from morning specimen collection are predicted to significantly improve detection of …

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Morning SARS-CoV-2 testing yields better detection of infection due to higher viral loads in saliva and nasal swabs upon waking

Alexander Viloria Winnett, Michael K. Porter, Anna E. Romano, Emily S. Savela et autres

ABSTRACT Background The analytical sensitivities of SARS-CoV-2 diagnostic tests span 6 orders of magnitude. Optimizing sample-collection methods to achieve the most reliable detection for a given sensitivity would increase the effectiveness of testing and minimize COVID-19 outbreaks. Methods From September 2020 to …

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Quantitative SARS-CoV-2 Viral-Load Curves in Paired Saliva Samples and Nasal Swabs Inform Appropriate Respiratory Sampling Site and Analytical Test Sensitivity Required for Earliest Viral Detection

Emily S. Savela, Alexander Viloria Winnett, Anna E. Romano, Michael K. Porter et autres

Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy. Low-analytical-sensitivity nasal-swab testing is commonly used for surveillance and symptomatic testing, but the ability of these tests to detect the …

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Coronary Artery Disease Evaluation and Management Considerations for High Risk Occupations: Commercial Vehicle Drivers and Pilots

Nadia R. Sutton, Shrilla Banerjee, Matthew M. Cooper, Armin Arbab‐Zadeh et autres

Optimal treatment of stable ischemic heart disease for those in the transportation industry is considered in the context of the individual's health, as well as with the perspective that sudden impairment could have catastrophic consequences for others. This article focuses on two …

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Quantitative SARS-CoV-2 viral-load curves in paired saliva and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity required for earliest viral detection

Emily S. Savela, Alexander Viloria Winnett, Anna E. Romano, Michael K. Porter et autres

Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and pre-symptomatic transmission, curb the spread of variants by travelers, and maximize treatment efficacy. Low-sensitivity nasal-swab testing (antigen and some nucleic-acid-amplification tests) is commonly used for surveillance and symptomatic testing, but the …

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SARS-CoV-2 Viral Load in Saliva Rises Gradually and to Moderate Levels in Some Humans

Alexander Viloria Winnett, Matthew M. Cooper, Natasha Shelby, Anna E. Romano et autres

Abstract Transmission of SARS-CoV-2 in community settings often occurs before symptom onset, therefore testing strategies that can reliably detect people in the early phase of infection are urgently needed. Early detection of SARS-CoV-2 infection is especially critical to protect vulnerable populations who …

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Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae

Emily S. Savela, Nathan G. Schoepp, Matthew M. Cooper, Justin C. Rolando et autres

Rapid antibiotic susceptibility testing (AST) for Neisseria gonorrhoeae (Ng) is critically needed to counter widespread antibiotic resistance. Detection of nucleic acids in genotypic AST can be rapid, but it has not been successful for β-lactams (the largest antibiotic class used to treat …

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Cause and Effect: Membranoproliferative Glomerulonephritis Type I (MPGN I) and Type II (MPGN II) Recur Frequently and Result in Significant Graft Loss.

Aubrey L. Gilbert, Matthew M. Cooper, Jennifer E. Verbesey, P. Weems et autres

Objective The primary objective of the study was to assess the risk of graft loss due to recurrent MPGN I and MPGN II compared with all other causes of graft failure. Methods All patients in UNOS database were considered for analysis. We …

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