Integrative Use of Cannabidiol, Melatonin, and Oxygen–Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases. A Case Report
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Le résumé fourni par la source
Background and Clinical Significance: Breast cancer is the most frequent malignancy in women. Metastatic breast cancer is considered a treatable but incurable condition, with a median overall survival of only 2–3 years. Among its subtypes, triple-negative breast cancer (TNBC) accounts for a high proportion of breast cancer-related deaths. It is characterized by an aggressive clinical course, early recurrence, and a strong propensity for visceral and brain metastases. Case Presentation: We report the case of a Caucasian woman who developed systemic disease recurrence with lung and mediastinal lymph node metastases, occurring two years after her primary diagnosis and treatment for TNBC. The patient received three months of chemotherapy combined with an adjuvant integrative protocol consisting of melatonin, cannabidiol, and oxygen–ozone therapy. This combined approach led to the complete disappearance of the lung nodules. Subsequently, stereotactic radiotherapy was performed and, in association with the ongoing integrative treatment, resulted in a significant reduction in mediastinal adenopathy. Introduction of immunotherapy, supported continuously by the same adjuvant strategy, achieved a complete and durable remission. Strikingly, the patient remained disease-free five years after the diagnosis of lung and mediastinal metastases. Conclusions: This clinical case highlights the potential benefit of using melatonin, cannabidiol, and oxygen–ozone therapy as part of an integrative approach in patients with aggressive metastatic TNBC. While it is not possible to establish causality from a single case, the sustained remission observed suggests that such unconventional adjuvant strategies could play a supportive role in enhancing the efficacy of standard oncologic therapies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Integrative Use of Cannabidiol, Melatonin, and Oxygen–Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases. A Case Report
- Date Crossref
- 19/01/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Università di Camerino pays non établi dans la noticeUniversité ou école supérieure
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Azienda Unità Sanitaria Locale 11 di Empoli pays non établi dans la noticeÉtablissement de santé
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University of Perugia pays non établi dans la noticeUniversité ou école supérieure
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University of Campania "Luigi Vanvitelli" pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli pays non établi dans la noticeÉtablissement de santé
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School of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Institute Ecomedica Empoli Department of Radiotherapy pays non établi dans la noticeStructure de recherche
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Specialization School of Hospital Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Scuola di Medicina e Chirurgia pays non établi dans la noticeInstitution
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“Maria Guarino” Foundation-AMOR No Profit Association pays non établi dans la noticeOrganisation à but non lucratif
Università di Camerino, Azienda Unità Sanitaria Locale 11 di Empoli et University of Perugia, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.