Vishal Singh

An Epidemiological Study of Sleep-Related Disorders and Their Association With Cardiovascular Risk Factors in an Adult Population (30-69 Years) of South Delhi

Vishal Singh, Farzana Sharmin Pamela Islam, Rambha Pathak, Aqsa Shaikh et autres

Background Sleep-related disorders (SRDs) are a major yet underdiagnosed public health burden in India, and community-level evidence linking them with cardiometabolic risk factors remains scarce. This study aimed to estimate the point prevalence of selected SRDs assessed by four validated screening questionnaires, …

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Determinants and Correlates of Occupational Skin Diseases and Workplace Risk Stratification in a Metal Casting Factory: A Cross-Sectional Study From a Rural Coastal Region of Southern India

Srikrishna Sulgodu Ramachandra, Shobhit Mohan, Vishal Singh, Priya Dubey et autres

Introduction Workers in metal casting industries are routinely exposed to high temperatures, hazardous chemicals, metal fumes, and dust, placing them at significant risk of occupational skin diseases (OSD). Despite the considerable morbidity and productivity loss associated with OSD, systematic assessment in the …

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Aquaporin‐4 and caveolin‐1 as mediators of fibrinogen‐driven cerebrovascular pathology in cerebral amyloid angiopathy

Vishal Singh, Nicholas Rochakim, Francesca Ferraresso, Khushi Garg et autres

INTRODUCTION: Cerebral amyloid angiopathy (CAA), marked by amyloid beta (Aβ) accumulation in perivascular spaces (PVSs), contributes to vascular injury and inflammation in Alzheimer's disease. The mechanisms underlying CAA-related vascular pathology remain unclear. Increasing evidence indicates fibrinogen, the main component in blood clots, …

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Pathological mechanisms of motor dysfunction in familial Danish dementia: insights from a knock-in rat model

Arnab Choudhury, Metin Yeşiltepe, Tammaryn Lashley, Vishal Singh et autres

Familial Danish Dementia (FDD) is a rare autosomal dominant neurodegenerative disorder caused by a mutation in the integral membrane protein 2B (ITM2b) gene. Clinically, FDD is characterized by cerebral amyloid angiopathy (CAA), cerebellar ataxia, and dementia. Notably, FDD shares several neuropathological features …

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Implications of Bismuth and Sulphide Nanoparticles for Cancer Therapy

Prakash Pandey, Vishal Singh, Gopal Rai, Mehwish Khan

This chapter explores the promising role of these nanoparticles in advancing cancer treatment. Nanoparticle-based therapies have emerged as a revolutionary approach due to their ability to enhance drug delivery, reduce side effects, and target cancer cells with high precision. This chapter begins …

A Comprehensive Review of the Clinical Evidence on the Efficacy, Effectiveness, and Safety of Silodosin for the Treatment of Benign Prostatic Hyperplasia

Omar Salim Akhtar, Vishal Singh, Shruti K. Dharmadhikari, Chaitany Bhargave et autres

Silodosin, a highly selective α1A-adrenoceptor blocker, is an effective treatment for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Despite its growing use, there remains a lack of comprehensive evidence evaluating the efficacy/effectiveness and safety of silodosin in BPH …

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Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model

Arnab Choudhury, Metin Yeşiltepe, Tammaryn Lashley, Vishal Singh et autres

Abstract Familial Danish Dementia (FDD) is a rare autosomal dominant neurodegenerative disorder caused by a mutation in the integral membrane protein 2B ( ITM2b ) gene. Clinically, FDD is characterized by cerebral amyloid angiopathy (CAA), cerebellar ataxia, and dementia. Notably, FDD shares …

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Composition of Gut Microbiota Dysbiosis and Functional Food to Treat Inflammatory Bowel Disease

Ashish Kumar Garg, Sumel Ashique, Vishal Singh, Gopal Rai et autres

The hallmark feature of inflammatory bowel disease (IBD) is the recurrent inflammation of the gastrointestinal tract, which encompasses a group of chronic medical disorders. It is generally accepted that changes in the gut microbiota and the host’s defense system play critical roles …

Role of nutraceuticals in neurological disease

Ashish Kumar Garg, Sweta Garg, Vishal Singh, Gopal Rai et autres

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Aquaporin-4 and Caveolin-1 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Cerebral Amyloid Angiopathy

Vishal Singh, Nicholas Rochakim, Francesca Ferraresso, Khushi Garg et autres

Cerebral Amyloid Angiopathy (CAA), characterized by amyloid-β (Aβ) accumulation within perivascular spaces (PVS), contributes to vascular damage and inflammation in Alzheimer's disease (AD). Despite its significance, the mechanisms driving Aβ deposition in PVS and the resulting vascular pathology remain poorly understood. Growing …

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DEVELOPMENT AND CHARACTERIZATION OF TRANSFERSOMES LOADED WITH EFINACONAZOLE: FORMULATION AND CHARACTERIZATION

Vishal Singh, Jaya Pandey

Obstructive Sleep Apnoea in adult Population in an Urban Area of Delhi, India: A Community-Based Epidemiological Study

Vishal Singh, Farzana Sharmin Pamela Islam, Rambha Pathak, Ashok Shah

Abstract Introduction: The objective of this study was to investigate the risk of obstructive sleep apnoea (OSA) and its association with cardiovascular and socio-demographic factors in the adult population of South Delhi, India. Materials and Methods: Employing a community-based cross-sectional design, authors …

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