Tim I. M. Malcolm

A simeprevir-inducible molecular switch for the control of cell and gene therapies

Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd et autres

Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To date, CID modules have been used primarily in …

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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Jan Pěnčík, Cécile Philippe, Michaela Schlederer, Emine Atas et autres

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in mPCa. Here …

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A novel molecular switch for control of cell and gene therapies based on a clinically approved small molecule

Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd et autres

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Paediatric Burkitt lymphoma patient‐derived xenografts capture disease characteristics over time and are a model for therapy

Sorcha Forde, Jamie D. Matthews, Leila Jahangiri, Liam C. Lee et autres

Burkitt lymphoma (BL) accounts for almost two-thirds of all B-cell non-Hodgkin lymphoma (B-NHL) in children and adolescents and is characterised by a MYC translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed in recent decades, including the lymphomes malins B …

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Challenging perspectives on the cellular origins of lymphoma

Tim I. M. Malcolm, Daniel James Hodson, Elizabeth A. Macintyre, Suzanne Dawn Turner

Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering …

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Abstract 671: Assessing the origins of anaplastic large cell lymphoma in murine models via forced lineage specificity of NPM-ALK expression in T cells

Tim I. M. Malcolm, Camilla Fairbairn, Katherine Hughes, Lukas Kenner et autres

Abstract Background: Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma representing 10-15% of all childhood non Hodgkin lymphomas, whereby those positive for aberrant expression of Anaplastic Lymphoma kinase (ALK) account for 50-80% of cases. The oncogene Nucleophosmin 1 (NPM)-ALK is …

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Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress

Tim I. M. Malcolm, Patrick Villarèse, Camilla Fairbairn, Laurence Lamant et autres

Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of …

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Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pěnčík, Michaela Schlederer, Wolfgang Gruber, Christine Unger et autres

Nature Communications 6: Article number:7736 (2015); Published: 22 July 2015; Updated: 26 October 2015 The affiliation details for Jan Pencik are incorrect in this Article. The correct affiliation details for this author are given below: Ludwig Boltzmann Institute for Cancer Research, Waehringerstrasse …

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ID: 263

Jan Pěnčík, Michaela Schlederer, Wolfgang Gruber, Christine Unger et autres

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STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pěnčík, Michaela Schlederer, Wolfgang Gruber, Christine Unger et autres

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 …

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Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin

Naushad Moti, Tim I. M. Malcolm, Rifat Hamoudi, Shahzad I. Mian et autres

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The demon drink

Tim I. M. Malcolm

Do elderly people really form a distinct group in terms of alcohol abuse? Tim Malcolm takes a sobering look at the facts

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