Peter F. Lais

Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis

Ryan M. Marquardt, Sara A. Grimm, San‐Pin Wu, Peter F. Lais et autres

Pregnancy requires a supportive uterine environment facilitated by steroid hormone–regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. Serum response factor (SRF) is a widely expressed transcription factor essential for mesenchymal cell growth and differentiation with noted …

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Image guided construction of a common coordinate framework for spatial transcriptome data

Peter F. Lais, Shawn Mishra, Kun Xiong, Gurinder S. Atwal et autres

Spatial transcriptomics is a powerful technology for high-resolution mapping of gene expression in tissue samples, enabling a molecular level understanding of tissue architecture. The acquisition entails dissecting and profiling micron-thick tissue slices, with multiple slices often needed for a comprehensive study. However, …

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Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development

Emily A. McGlade, Jiude Mao, Kalli K. Stephens, Ryan M. Marquardt et autres

More than 60% of pregnancy losses occur during the first trimester, highlighting the need to understand the role of the oviduct in early pregnancy. In this study, we conditionally ablated the classical progesterone receptor ( Pgr ) in oviductal epithelial cells, called …

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Image guided construction of a common coordinate framework for spatial transcriptome data

Peter F. Lais, Shawn Mishra, Kun Xiong, Gurinder S. Atwal et autres

Abstract Spatial transcriptomics is a powerful technology for high-resolution mapping of gene expression in tissue samples, enabling a molecular level understanding of tissue architecture. The acquisition entails dissecting and profiling micron-thick tissue slices, with multiple slices often needed for a comprehensive study. …

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Early and fair COVID-19 outcome risk assessment using robust feature selection

Felipe Giuste, Lawrence He, Peter F. Lais, Wenqi Shi et autres

Personalized medicine plays an important role in treatment optimization for COVID-19 patient management. Early treatment in patients at high risk of severe complications is vital to prevent death and ventilator use. Predicting COVID-19 clinical outcomes using machine learning may provide a fast …

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Integrating Multi-Omics Data With EHR for Precision Medicine Using Advanced Artificial Intelligence

Tong Li, Wenqi Shi, Monica Isgut, Yishan Zhong et autres

With the recent advancement of novel biomedical technologies such as high-throughput sequencing and wearable devices, multi-modal biomedical data ranging from multi-omics molecular data to real-time continuous bio-signals are generated at an unprecedented speed and scale every day. For the first time, these …

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Explainable synthetic image generation to improve risk assessment of rare pediatric heart transplant rejection

Felipe Giuste, Ryan Christopher Sequeira, Vikranth Keerthipati, Peter F. Lais et autres

Expert microscopic analysis of cells obtained from frequent heart biopsies is vital for early detection of pediatric heart transplant rejection to prevent heart failure. Detection of this rare condition is prone to low levels of expert agreement due to the difficulty of …

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Squeezing in the Jaynes-Cummings model without the RWA

Peter F. Lais, T. Steimle

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Dynamics of the Pseudo‐E ⊗ ε Jahn‐Teller Hamiltonian. A Quantum Optical Approach

Peter F. Lais, Michael Kraus

Abstract New dynamical aspects are investigated of the pseudo‐E ⊗ ε‐Jahn‐Teller Hamiltonian (PJTH). A close relation is found between the PJTH and the Jaynes‐Cummings model in quantum optics. After using a continued fraction method for the diagonalization of the Hamiltonian the exact …

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Comment on “the effects of negative binomial field distribution on rabi oscillations on a two level atom”

Peter F. Lais

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Exact solution of the E⊗ε Jahn-Teller and Rabi Hamiltonian by generalised spheroidal wavefunctions?

H.G. Reik, Peter F. Lais, M E Stutzle, Michal Doucha

The Schrodinger equation for the E⊗ε Jahn-Teller and Rabi systems in Bargmann's Hilbert space (1962) is a system of two ordinary differential equations of first order for the spin up and down components of the wavefunctions. This system has two regular and …

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