Satyawan Jadhav

Heterogeneity in Activation and Immunomodulatory Responses in Heart, Kidney and Lung Endothelial Cells

Satyawan Jadhav, Viet Do, Alvin T. Kho, Sayantan Bose et autres

Purpose: Recent studies using single-cell RNA sequencing have revealed that there is considerable heterogeneity in endothelial cells (EC) phenotypes as well as notable differences in microvascular EC subpopulations across various organs. We wish to evaluate if organ-specific gene expression signatures in EC …

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Abstract 4135443: A Phase 1, Single Ascending Dose Study to Evaluate ALN-TTRsc04, a Next-Generation RNA Interference Therapeutic, in Healthy Participants for Potential Treatment of Transthyretin Amyloidosis

A.M. Murad, Maxwell J. Lasko, Prajakta Badri, Satyawan Jadhav et autres

Introduction: Transthyretin amyloidosis (ATTR) is a progressive, debilitating, fatal disease caused by deposition of misfolded toxic transthyretin (TTR) amyloid fibrils in multiple organs and tissues. Major ATTR manifestations include polyneuropathy and cardiomyopathy. Ongoing amyloid deposition drives rapid progression of ATTR, leading to …

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Disease Progression Modeling of Stargardt’s disease

Satyawan Jadhav, Nitin Mehrotra, Megan Melch, Prajakta Badri et autres

Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia

Satyawan Jadhav, Benny Amore, Howard N. Bockbrader, Ryan L. Crass et autres

Abstract Population pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic (popPK/PD) relationship between bempedoic acid concentrations and serum low-density lipoprotein cholesterol (LDL-C) from baseline were characterized. A two-compartment disposition model with a transit absorption compartment and linear elimination best described bempedoic acid …

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Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model

Satyawan Jadhav, Ryan L. Crass, Sunny Chapel, Michael Kerschnitzki et autres

AIMS: Many patients are unable to achieve guideline-recommended LDL cholesterol (LDL-C) targets, despite taking maximally tolerated lipid-lowering therapy. Bempedoic acid, a competitive inhibitor of ATP citrate lyase, significantly lowers LDL-C with or without background statin therapy in diverse populations. Because pharmacodynamic interaction …

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Pharmacodynamic effect of bempedoic acid and statin combinations: Predictions from a dose-response model

Satyawan Jadhav, Ryan L. Crass, Sunny Chapel, Michael Kerschnitzki et autres

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Pharmacokinetics and Determination of Tumor Interstitial Distribution of a Therapeutic Monoclonal Antibody Using Large-Pore Microdialysis

Vipada Khaowroongrueng, Satyawan Jadhav, Muzeeb Syed, Mohammad Ahsanul Akbar et autres

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Discovery of 5-(2-chloro-4′-(1H-imidazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD

Muthukaman Nagarajan, Sanjay Deshmukh, Shital Tondlekar, Macchindra Tambe et autres

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Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Muthukaman Nagarajan, Sanjay Deshmukh, Macchindra Tambe, Dnyandeo Pisal et autres

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Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

Muthukaman Nagarajan, Macchindra Tambe, Sanjay Deshmukh, Dnyandeo Pisal et autres

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Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis

Satyawan Jadhav, Vipada Khaowroongrueng, Matthias Fueth, Michael B. Otteneder et autres

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Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

Muthukaman Nagarajan, Macchindra Tambe, Mahamadhanif S. Shaikh, Dnyandeo Pisal et autres

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