Mahamadhanif S. Shaikh

CCDC 1986001: Experimental Crystal Structure Determination

Babita Kushwaha, Narva Deshwar Kushwaha, Tanya Parish, Junitta Guzman et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2049298: Experimental Crystal Structure Determination

Babita Kushwaha, Narva Deshwar Kushwaha, Tanya Parish, Junitta Guzman et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

A New Class of Linezolid‐Based Molecules as Potential Antimicrobial and Antitubercular Agents: A Rational Approach

Babita Kushwaha, Narva Deshwar Kushwaha, Tanya Parish, Junitta Guzman et autres

Abstract A total of 19 linezolid‐based novel molecules ( 6 a – d , 8 a – d and 10 a – k ) were synthesized by utilizing a simple and convenient synthetic method. Structures of all the novel derivatives were established …

Afrique du Sud, us (code pays fourni par la source)

Synthesis and Biological Evaluation of Novel Carbazole Hybrids as Promising Antimicrobial Agents

Mahamadhanif S. Shaikh, Balakumar Chandrasekaran, Mahesh B. Palkar, Ashish M. Kanhed et autres

Two series of carbazole analogs of 8-methoxy-N-substituted-9H-carbazole-3-carboxamides (series 1) and carbazolyl substituted rhodanines (series 2) were synthesized through facile synthetic routes. All the final compounds from these two series were evaluated for their preliminary in vitro antifungal and antibacterial activity against four …

Afrique du Sud, jo (code pays fourni par la source)

Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA

Mahamadhanif S. Shaikh, Ashish M. Kanhed, Balakumar Chandrasekaran, Mahesh B. Palkar et autres

Afrique du Sud, fr (code pays fourni par la source)

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Muthukaman Nagarajan, Sanjay Deshmukh, Macchindra S. Tambe, Dnyandeo Pisal et autres

in (code pays fourni par la source)

Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

Muthukaman Nagarajan, Macchindra S. Tambe, Sanjay Deshmukh, Dnyandeo Pisal et autres

in (code pays fourni par la source)

Design, synthesis and QSAR studies of 2-amino benzo[d]thiazolyl substituted pyrazol-5-ones: novel class of promising antibacterial agents

Mahesh B. Palkar, Aniket Patil, Girish A. Hampannavar, Mahamadhanif S. Shaikh et autres

in, Afrique du Sud (code pays fourni par la source)

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

Muthukaman Nagarajan, Macchindra S. Tambe, Mahamadhanif S. Shaikh, Dnyandeo Pisal et autres

in (code pays fourni par la source)

Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor

Muthukaman Nagarajan, Sanjay Deshmukh, Neelam Sarode, Shital Tondlekar et autres

in (code pays fourni par la source)

Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents

Girish A. Hampannavar, Rajshekhar V. Karpoormath, Mahesh B. Palkar, Mahamadhanif S. Shaikh et autres

Series of styryl hydrazine thiazole hybrids inspired from dehydrozingerone (DZG) scaffold were designed and synthesized by molecular hybridization approach. In vitro antimycobacterial activity of synthesized compounds was evaluated against Mycobacterium tuberculosis H37Rv strain. Among the series, compound 6o exhibited significant activity (MIC …

Afrique du Sud, in (code pays fourni par la source)

A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids

Rajesh A. Rane, Sivanandhan Karunanidhi, Kavita R. Jain, Mahamadhanif S. Shaikh et autres

Isatin as an alkaloidal framework have consistently attracted attention of medicinal chemist towards development of wide range of novel therapeutic agents. This review report has discussed significant isatin lead molecules and their derivatives which have shown promising biological potential in recent times. …

Afrique du Sud (code pays fourni par la source)