Xiaolin Ni

A foundational model encodes deep phenotyping data and enables diverse downstream applications

Qiyang Hong, C H U N Q I Wang, Wenqian Wu, Yuyan Li et autres

Deep phenotyping data are essential for understanding disease mechanisms and individual health trajectories. However, its unprecedented scale and complexity pose significant analytical challenges that conventional approaches struggle to address. Here, we introduce ukbFound, a foundation model that encoded thousands of individual-level traits …

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The Immune Cell Atlas of “Longevity Molecular Tag”: Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms

Huabin Su, Shihui Fu, Fansen Ji, Liuguan Liang et autres

ABSTRACT Immunosenescence represents a critical aspect of the aging process. Centenarians, serving as a nature model of “healthy aging,” demonstrate a distinctive immune “compensatory adaptation” mechanism that contributes to the maintenance of immune homeostasis. However, the specific immune cell subsets involved and …

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Genetic determinants of gene expression noise and its role in complex trait variation

Yuexuan Long, Xiaolin Ni, Ting-Wei Chen, Qiyang Hong et autres

Even genetically identical cells in homogeneous environments exhibit heterogeneous mRNA abundance, typically called "gene expression noise," which is involved in key cellular activities, evolutionary processes, and disease mechanisms. However, determinants of the gene expression noise and its functional role in variations of …

cn, us (code pays fourni par la source)

Psychological states mediate the relationship between sleep quality and frailty among older adults

Huabin Su, Yanyan Lin, Caiyou Hu, Yuan Lv et autres

Objective: Frailty prevalence is high among older adults. While the association between poor sleep quality and frailty is established, the mediating role of psychological states (anxiety/depression) and the moderating influence of multidimensional factors (physiological conditions, dietary habits, and lifestyle factors) on this …

cn, us (code pays fourni par la source)

Learning Personalised Human Internal Cognition from External Expressive Behaviours for Real Personality Recognition

Xiangyu Kong, Zhihao Guo, Jiayan Gu, Xiaolin Ni et autres

Automatic real personality recognition (RPR) aims to evaluate human real personality traits from their expressive behaviours. However, most existing solutions generally act as external observers to infer observers' personality impressions based on target individuals' expressive behaviours, which significantly deviate from their real …

Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis

Zi‐Wei Hong, Xiaolin Ni, Liying Zhou, Hong Ji et autres

cn, se (code pays fourni par la source)

The relationship between anxiety and quality of life among people with epilepsy: The mediating effect of depression

Yuan Lv, Mei Liang, Dongdong Jiang, Xiaoqin Gan et autres

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ToolFactory: Automating Tool Generation by Leveraging LLM to Understand REST API Documentations

Xiaolin Ni, Qiuyang Wang, Pengyu Hong

LLM-based tool agents offer natural language interfaces, enabling users to seamlessly interact with computing services. While REST APIs are valuable resources for building such agents, they must first be transformed into AI-compatible tools. Automatically generating AI-compatible tools from REST API documents can …

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Clinical Analysis of Nursing Care of Acute Myocardial Infarction in Cardiovascular Medicine

Xiaolin Ni

Objective: In order to effectively improve the treatment and nursing effect of acute myocardial infarction, improve the cardiovascular function and psychological state of patients, to further explore the methods and effects of cardiovascular medical treatment and nursing of acute myocardial infarction, and …

Constructing Safety Management Systems in Modern Industry and Trade Enterprises: A STAMP-Based Approach

Xiaomeng Xu, Donghui Li, Ziheng Wang, Lingjie Zhu et autres

With the burgeoning landscape of new enterprises and business paradigms, industrial and trade enterprises are facing escalating pressure to ensure operational safety. Conventional safety management mechanisms have proven to be inadequate for adapting to the dynamic market demands and intricacies of modern …

cn (code pays fourni par la source)

Genetic determinants of gene expression noise and its role in complex trait variation

Yuexuan Long, Xiaolin Ni, Ting-Wei Chen, Qiyang Hong et autres

ABSTRACT Even genetically identical cells in a homogeneous environment can exhibit heterogeneous mRNA abundance because of widely unavoidable random fluctuations, typically referred to as ‘gene expression noise’. Recent studies showed that noise, not just a nuisance, is indeed involved in cellular activities …

cn, us, in (code pays fourni par la source)

Deep Learning-Based 3D Reconstruction of Interior Surface Defects in Post-Earthquake Buildings

Shuhua Gao, Xiaolin Ni, Jing Wang, Zhengfang Wang

Frequent moderate to minor earthquakes often cause significant structural damage to buildings, manifested as cracks and spalling on interior surfaces. These defects compromise structural integrity and can lead to catastrophic collapses during aftershocks, posing significant risks to rescue personnel. Therefore, promptly assessing …

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