Braulio Bonilla

Behavioral compensation masks morphological trade-offs in the locomotion of the terrestrial hermit crab Coenobita compressus

Lucía Morales, Braulio Bonilla, Candelario Rodríguez, Yostin Añino et autres

The trade-off between protection and mobility is a central principle in functional ecology and is particularly relevant in terrestrial hermit crabs, which depend on gastropod shells for defense while potentially incurring locomotor costs. Under the trade-off hypothesis, heavier or asymmetric shells are …

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esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions

Braulio Bonilla, Benjamin J. Patty, Snehal Sambare, Job Dekker et autres

The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucleosomes. Nucleosome remodeling complexes hydrolyze ATP to translocate DNA and thereby mobilize histone proteins. While nucleosome remodeling complexes …

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The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Tony M. Mertz, Nima Mosammaparast, Piotr A. Mieczkowski, Sarah R Hengel et autres

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as …

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esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions

Braulio Bonilla, Benjamin J. Patty, Snehal Sambare, Job Dekker et autres

The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucleosomes. Nucleosome remodeling complexes hydrolyze ATP to translocate DNA and thereby mobilize histone proteins. While nucleosome remodeling complexes …

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The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination

Adeola A Fagunloye, Alessio De Magis, Jordan Little, Tanis J. Dorwart et autres

Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis. Here we examine how yeast cells require the Shu complex for coping with MMS-induced lesions during DNA replication. We …

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Daily activity patterns in agoutis (Dasyprocta spp) in response to relaxed predation

Dumas Gálvez, Emilio Romero, Daniel Murcia-Moreno, Braulio Bonilla et autres

Animals' fitness is determined in a large proportion by the balance in energetic requirements maintained during daily activities, in response to environmental factors. Predation is a major environmental factor influencing the activity patterns of prey, and the deployment of adaptive responses to …

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Report of coloration anomalies in mammals from Panama

Rogemif Fuentes, Melquiades Castillo, Ricardo Moreno, Helio Quintero-Arrieta et autres

Coloration anomalies are widespread across the animal kingdom; however, they pass underreported for some taxa or are extremely rare, like in the case of mammals. Three of those anomalies are albinism, leucism, and erythrism, each of which generates atypical colorations in white …

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The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Braulio Bonilla, Alexander J. Brown, Sarah R Hengel, Kyle Rapchak et autres

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as …

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Author response: The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Braulio Bonilla, Alexander J. Brown, Sarah R Hengel, Kyle Rapchak et autres

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The Shu Complex Prevents Mutagenesis and Cytotoxicity of Single-Strand Specific Alkylation Lesions

Braulio Bonilla, Alexander J. Brown, Sarah R Hengel, Kyle Rapchak et autres

ABSTRACT Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans, express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question …

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The role of the yeast Shu complex in the error-free bypass of abasic sites and 3-Methylcytosines

Braulio Bonilla

Accurate DNA replication is critical to prevent genomic instability, which is a hallmark of cancer. Homologous recombination (HR) is responsible for error-free DNA damage bypass during replication. The yeast Shu complex is a recombination mediator primarily specialized in preventing replication-associated mutagenesis from …

RAD51 Gene Family Structure and Function

Braulio Bonilla, Sarah R Hengel, McKenzie K. Grundy, Kara A. Bernstein

Accurate DNA repair and replication are critical for genomic stability and cancer prevention. RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double-strand break repair, replication stress, and meiosis. RAD51 is an ATPase that forms a …

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