Jianhui Wei

GWAS-Informed Candidate Genetic Variants and Gene–Gene/Gene–Environment Interaction Patterns Associated with Intervertebral Disc Degeneration: A Chinese Han Case–Control Study

Ridan Lei, Mengyuan Zhang, Manjun Luo, Xiaorui Ruan et autres

Background/Objectives: Intervertebral disc degeneration (IDD) is a multifactorial spinal degenerative condition influenced by inherited susceptibility and environmental exposures. Genetic evidence from Chinese Han populations remains limited. This study aimed to evaluate GWAS-informed and previously reported candidate single-nucleotide polymorphisms (SNPs) associated with IDD …

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Impact of the Oxide Film Formed During the Seeding Process of Single-Crystal Superalloys

Bowen Cheng, LV Li, Dexin Ma, Jianhui Wei et autres

The impact of the oxide film in the remelted zone of a seed on the epitaxial solidification of single-crystal superalloys was investigated, with a specific focus on clarifying the hindrance mechanism of complex compositional oxide films during the epitaxial growth process. Experimental …

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Development and External Validation of an Explainable Machine-Learning Model for Predicting Postoperative Pulmonary Complications in Older Adults Undergoing Degenerative Spine Surgery

Ridan Lei, Jun Ou, Yuehua Chen, Manjun Luo et autres

Background: Postoperative pulmonary complications (PPCs) remain common in older adults undergoing degenerative spine surgery and are associated with adverse outcomes. We aimed to develop and externally validate an explainable machine-learning model using routinely available perioperative variables to estimate individual PPC risk. Methods: …

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Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Jianhui Wei, Peng Huang, Letao Chen, Taoyue Yang et autres

Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart development, and their gene polymorphisms may contribute …

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Jianhui Wei, Peng Huang, Letao Chen, Taoyue Yang et autres

Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart development, and their gene polymorphisms may contribute …

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang et autres

Background Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart development, and their gene polymorphisms may …

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An evaluation of factors associated with hypertension in children and adolescents with obesity

Kexin Zhou, Zili Cai, Shiting Xiang, Jianhui Wei et autres

Introduction: Childhood hypertension and obesity are among the most prevalent health conditions worldwide, with obesity increasing the risk of hypertension in children. However, there has been limited focus on children with obesity. Methods: To identify the risk factors of hypertension in children …

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Formation Mechanisms of Chilled Layer on the Perimeter of Superalloy Seed

Yangpi Deng, Dexin Ma, Jianhui Wei, Yuan Zhao et autres

The seeding technique is the only way to precisely control the crystal orientation of single-crystal superalloy castings. However, an inevitable assembly gap exists between the seed and the mold cavity in practice, whose role in defect formation remains insufficiently understood. To elucidate …

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Alloy design integrating natural language processing and machine learning: breakthrough development of low-cost, high-performance Ni-based single-crystal superalloys

Zi Wang, Juncheng Wang, Wei Yu, Yuxuan Chen et autres

The traditional design of single-crystal superalloys relies heavily on trial-and-error experimentation, which is time-consuming and costly. Here, we present an intelligent alloy design strategy that integrates natural language processing (NLP) and machine learning (ML). A domain-specific NLP model was developed to automatically …

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Association of BMAL1 and CLOCK Gene Polymorphisms with Preeclampsia Risk with Subtype Analysis

Fan Xia, Peiwen Wang, Ziye Li, Jiehua Wei et autres

Preeclampsia (PE), a major cause of maternal and perinatal morbidity, is a hypertensive pregnancy disorder with poorly defined pathogenesis. While dysregulation of core circadian genes including brain and muscle ARNT-like 1 (BMAL1; also termed ARNTL) and circadian locomotor output cycles kaput (CLOCK) …

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[Chain mediating role of family care and emotional management between social support and anxiety in primary school students].

Z. J. Li, Jianhui Wei, Xiao-Rui Ruan, Yuting Wen et autres

OBJECTIVES: To investigate the chain mediating role of family care and emotional management in the relationship between social support and anxiety among rural primary school students. METHODS: A questionnaire survey was conducted among students in grades 4 to 6 from four counties …

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High strength of a nickel-based superalloy achieved by multi-phase synergistic precipitation strengthening

Jianhui Wei, Shengnan Ma, Changchang Liu, Yanghuanzi Li et autres

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