Jian Weng

M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy

Weibei Sheng, Lian Li, Jin Zhao, Shouye Ma et autres

The inflammatory microenvironment mediated by synovial macrophages, particularly the pro-inflammatory M1 subtype, plays a central role in OA progression and represents a critical therapeutic target. However, delivery strategies that enable efficient and selective targeting of M1 macrophages for modulating the inflammatory microenvironment …

cn (code pays fourni par la source)

A migrasome-related lncRNA signature predicts prognosis and immune response in hepatocellular carcinoma: Implications for biomarker discovery and therapeutic targeting

Haotian Qin, Tiantian Qi, Min Liu, Weibei Sheng et autres

Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death, with limited response rates to immunotherapy. Identifying novel biomarkers to predict prognosis and guide treatment is urgently needed. Methods: Using TCGA-LIHC data, we identified migrasome-related long non-coding RNAs (MRlncRNAs) associated with …

hk, cn (code pays fourni par la source)

Multifunctional Biomimetic Nanomedicine for Osteoarthritis Alleviation by Mitigating Cartilage Degeneration and Promoting Cartilage Regeneration

Yaohang Yue, Yihao Wei, Weibei Sheng, Siyang Cao et autres

Osteoarthritis (OA) is a long-standing degenerative condition of the joints, defined by the progressive loss of articular cartilage accompanied by ongoing inflammation. For OA to be effectively treated, reducing cartilage breakdown and enhancing its regeneration are essential objectives. However, OA involves chronic …

cn, hk (code pays fourni par la source)

Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC

Haotian Qin, Juan Xu, Yaohang Yue, Meiling Chen et autres

Background: Disulfidptosis is a newly discovered form of cell death associated with tumorigenesis, particularly under oxidative stress and metabolic disorder conditions. Currently, the biological mechanisms of disulfidptosis-related genes (DRGs) in head and neck squamous cell carcinoma (HNSCC) remain unclear. Methods: The study …

cn (code pays fourni par la source)

M1 Macrophage-Targeted Glucose-Functionalized Nanoparticles for Berberine Delivery and Inflammatory Microenvironment Remodeling in Osteoarthritis Therapy

Weibei Sheng, Lian Li, Jin Zhao, Shaohua Ma et autres

cn (code pays fourni par la source)

Comprehensive analysis of cuproptosis-related prognostic gene signature and tumor immune microenvironment in HCC

Haotian Qin, Weibei Sheng, Geng Zhang, Qi Yang et autres

Background: Copper is an indispensable mineral element involved in many physiological metabolic processes. Cuproptosis is associated with a variety of cancer such as hepatocellular carcinoma (HCC). The objective of this study was to examine the relationships between the expression of cuproptosis-related genes …

cn (code pays fourni par la source)

Identification and verification of m7G-Related genes as biomarkers for prognosis of sarcoma

Haotian Qin, Weibei Sheng, Jian Weng, Guoqing Li et autres

Background: Increasing evidence indicates a crucial role for N7-methylguanosine (m7G) methylation modification in human disease development, particularly cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. However, …

cn (code pays fourni par la source)