K.I. Kivirikko

Contents, Vol. 56, 1991

M. Vercruyssen, Patrick Van Oostveldt, J. Leroy, Frank Speleman et autres

Title Page / Table of Contents / Abstracts

M. Vercruyssen, Patrick Van Oostveldt, J. Leroy, Frank Speleman et autres

Calendar of Events 1991 — 1992

M. Vercruyssen, Patrick Van Oostveldt, J. Leroy, Frank Speleman et autres

We very much welcome information on upcoming events that may be o f interest to our readers.For details please see the Editor's Announcement on pg. 1,

Author Index Vol. 56, 1991

M. Vercruyssen, Patrick Van Oostveldt, J. Leroy, Frank Speleman et autres

Relevance of Posttranslational Modifications for the Arthritogenicity of Type II Collagen

Linda K. Myers, Johanna Myllyharju, Minna Nokelainen, David Douglass Brand et autres

To establish the role of posttranslational modification in modulating the immune response to collagen, recombinant human type II collagen (rCII) was produced using a yeast expression system (rCII(pic)) and a baculovirus expression system (rCII(bac)). The biosynthesis of CII requires extensive posttranslational modification …

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Expression of recombinant human type I‒III collagens in the yeast Pichia pastoris

Johanna Myllyharju, Minna Nokelainen, Annamari Vuorela, K.I. Kivirikko

An efficient expression system for recombinant human collagens will have numerous scientific and medical applications. However, most recombinant systems are unsuitable for this purpose, as they do not have sufficient prolyl 4-hydroxylase activity. We have developed methods for producing the three major …

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Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements.

Kaisa Tasanen, Jouko Oikarinen, K.I. Kivirikko, Taina A. Pihlajaniemi

Protein disulfide isomerase (PDI) is a highly unusual multifunctional polypeptide that is identical to the beta-subunit of prolyl 4-hydroxylase, a cellular thyroid hormone-binding protein and a subunit of the microsomal triglyceride transfer protein complex, and very similar to a polypeptide functioning in …

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