Erkka Valo

Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease

Karina Barreiro, Jenni Karttunen, Erkka Valo, Essi Viippola et autres

Abstract Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by …

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Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci

Joanne B. Cole, Emma H. Dahlström, Damian Fermin, Yogesh Gupta et autres

Key Points Comprehensive genome-wide association study of eGFR in diabetes, accounting for diabetes duration, kidney disease, and known modifiers, identified novel genetic effects. Incorporation of various kidney multi-omics data provides supporting evidence for the role of novel genome-wide association study loci in …

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Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

Erkka Valo, Anne Richmond, Stefan Mutter, Emma H. Dahlström et autres

Abstract Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary …

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Selected miRNAs in urinary extracellular vesicles show promise for non-invasive diagnostics of diabetic kidney disease

Karina Barreiro, Jenni Karttunen, Erkka Valo, Essi Viippola et autres

Abstract Diabetic kidney disease is a growing health burden that lacks specific early non-invasive diagnostic procedures. To approach a solution for this clinical need, we sequenced microRNAs of urinary extracellular vesicles and performed biomarker discovery by small RNA sequencing in a type …

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Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease

Jani K. Haukka, Anni A. Antikainen, Erkka Valo, Anna Syreeni et autres

Abstract Aims/hypothesis Diabetic kidney disease (DKD) is a severe diabetic complication that affects one third of individuals with type 1 diabetes. Although several genes and common variants have been shown to be associated with DKD, much of the predicted inheritance remains unexplained. …

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Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

Erkka Valo, Anne Richmond, Stefan Mutter, Archie Campbell et autres

Abstract Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary …

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Whole-exome and Whole-genome Sequencing of 1097 Individuals with Type 1 Diabetes Reveals Novel Genes for Diabetic Kidney Disease

Jani K. Haukka, Anni A. Antikainen, Erkka Valo, Anna Syreeni et autres

Abstract Background and hypothesis Diabetic kidney disease (DKD) is a severe diabetic complication affecting one third of individuals with type 1 diabetes. Although several genes and common variants have been associated with DKD, much of the predicted inheritance remain unexplained. Here, we …

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Metabolomic and Transcriptomic Reveal Signature of Citrate Homeostasis in Diabetic Kidney Disease

Soumya Maity, Christine P. Limonte, Erkka Valo, Guanshi Zhang et autres

Background: Kidneys are highly metabolic organs, and the TCA cycle primarily fulfills the enormous energy required to maintain their normal function. In our previous cross-sectional study, low urinary citrate was associated with chronic kidney disease progression in Type 2 Diabetic patients. In …

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Medication profiling in women with type 1 diabetes highlights the importance of adequate, guideline-based treatment in low-risk groups

Raija Lithovius, Stefan Mutter, Erika B. Parente, Ville‐Petteri Mäkinen et autres

Abstract Effective treatment may prevent kidney complications, but women might be underprescribed. Novel, data-driven insights into prescriptions and their relationship with kidney health in women with type 1 diabetes may help to optimize treatment. We identified six medication profiles in 1164 women …

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Rate of Kidney Function Decline is Associated With Kidney and Heart Failure in Individuals With Type 1 Diabetes

Niina Sandholm, Erkka Valo, Jaakko Tuomilehto, Valma Harjutsalo et autres

Introduction: Diabetes is the most common cause of chronic kidney disease (CKD). Urinary albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR) are commonly used to monitor the onset and progression of diabetic kidney disease (DKD). We studied if the preceding …

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Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo et autres

Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney …

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Supplementary Data from Signal Transducers and Activators of Transcription 5a–Dependent Cross-talk between Follicular Lymphoma Cells and Tumor Microenvironment Characterizes a Group of Patients with Improved Outcome after R-CHOP

Minna Taskinen, Erkka Valo, Marja‐Liisa Karjalainen‐Lindsberg, Sampsa Hautaniemi et autres

Supplementary Data from Signal Transducers and Activators of Transcription 5a–Dependent Cross-talk between Follicular Lymphoma Cells and Tumor Microenvironment Characterizes a Group of Patients with Improved Outcome after R-CHOP