Fügen Aker

FGFR1::TACC1 fusion in mixed-morphology pediatric glioneuronal tumors: Report of two cases

Erva Bengu Balaban Yilmaz, Neşe Yeldir, Cansu Sönmez, Aslı Çakır et autres

To the Editor, Pediatric low-grade gliomas and glioneuronal tumors often exhibit overlapping histological features that pose diagnostic challenges, particularly in small biopsy specimens. We present two pediatric cases of recurrent glioneuronal tumors with mixed histological patterns, both harboring FGFR1::TACC1 fusions detected by …

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A Case of Leukocytoclastic Vasculitis Related to Acute Parvovirus B19 Infection

Eda Ozturk, Serpil Erol, Fügen Aker, Şirin Yaşar

Parvovirus B19 (PVB19) infection can cause various clinical presentations. While mostly erythema infectiosum, transient aplastic crisis, and fetal hydrops are seen, it rarely causes myocarditis, hepatitis, or vasculitis. We report a patient admitted with fever, fatigue, arthralgia, and rash. Although there was …

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Invasive lobular breast carcinoma variants; clinicopathological features and patient outcomes

Ayşegül Aktaş, Meryem Günay Gürleyik, Doğukan Akkuş, Zekeriya Ucur et autres

INTRODUCTION: An understanding of the differences among the invasive lobular breast carcinoma (ILC) variants is crucial for risk stratification, and tailored treatment planning. This article compares variants of ILC according to their clinical outcomes and histopathological features. PATIENTS AND METHODS: Patients diagnosed …

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P072: The Relationship Between the Density of Cancer-Associated Fibroblasts in the Peritumoral Stroma and Clinicopathological Data in Breast Cancer Patients (PERICAFS)

Dilek Evyapan Akkuş, Meryem Günay Gürleyik, Fügen Aker, Sibel Aydın Aksu et autres

An interpretable framework for inter-observer agreement measurements in TILs scoring on histopathological breast images: A proof-of-principle study

Abdulkerim Çapar, Dursun Ali Ekinci, Mucahit Ertano, Muhammad Khalid Khan Niazi et autres

Breast cancer, a widespread and life-threatening disease, necessitates precise diagnostic tools for improved patient outcomes. Tumor-Infiltrating Lymphocytes (TILs), reflective of the immune response against cancer cells, are pivotal in understanding breast cancer behavior. However, inter-observer variability in TILs scoring methods poses challenges …

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Evaluation of prognostic significance of histopathological characteristics and tumor-infiltrating lymphocytes for pancreatic cancer survival

Kadir Çorbacı, Günay Gürleyik, Aylin Gönültaş, Fügen Aker et autres

With a 5-year survival of ˂ 10%, pancreatic cancer is one of the leading causes of cancer-related deaths. Given the role of the distribution of tumor-infiltrating lymphocyte (TILs) subtypes in the tumor and its microenvironment in predicting prognosis, the development of new …

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Bilateral primary angiosarcoma of the breast after reduction mammoplasty: An extremely rare case and literature review

Cansu Sönmez, Erhan Ekren, Yaşar Kaan Akgök, Berfin Ekin Gözükara Yıldız et autres

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Relationship between immune checkpoint proteins and neoadjuvant chemotherapy response in breast cancer

Umut Kina Kilicaslan, Başak Aru, Sibel Aydın Aksu, Fügen Aker et autres

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Küçük hücre dışı akciğer kanserlerinde immünhistokimyasal C-ERBB2 pozitivitesinin klinikopatolojik ve prognostik önemi

Ayşe Nur Toksöz Yıldırım, Fügen Aker, Murat Erkan

Amaç: Meme ve mide karsinomlarında tedavi ve prognozda önemli rol oynayan C-ERBB2’nin küçük hücreli dışı akciğer karsinomlarında (KHDAK) önemi bilinmemektedir. Bu nedenle C-ERBB2’nin KHDAK’lardaki rolünü ve önemini ortaya koymak, ileride hedefe yönelik tedavide olası kullanım durumunda Türkiye’deki hastalardaki durumunu saptamaya yönelik pilot …

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Retrospective Evaluation of Cases Undergoing Stereotaxic Brain Biopsy

Abdullah Yolcu, Ezgi Akar, Fügen Aker, Selin Tural Emon

Abstract Objective: The aim of this study is to evaluate the demographic, radiological and histopathological findings, tumoral biomarkers, and survival rates of patients who underwent a stereotactic brain biopsy and those diagnosed with glioblastoma, metastasis, and lymphoma, and the changes in the …

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¿La quimioterapia neoadyuvante proporciona algún beneficio para la desescalada quirúrgica en el cáncer de mama HER2 (Ó?) luminal B?

Ayşegül Aktaş, Meryem Gunay-Gurleyik, Fügen Aker, Yasar Kaan-Akgok et autres

BACKGROUND: The use of neoadjuvant chemotherapy (NAC) in less aggressive breast cancer (BC) is controversial. OBJECTIVE: To investigate the effect of neoadjuvant chemotherapy in HER2 negative luminal B breast cancer. PATIENTS AND METHODS: Patients between January 2016 and December 2021 were retrospectively …

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Could cytology supplant frozen section for intraoperative evaluation of thoracic lesions? A single institutional experience in a developing country

Zuhal Kuş Silav, Cansu Sönmez, Bülent Aydemir, Mehmet Yıldırım et autres

BACKGROUND: The diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey). METHODS: All 197 subsequent patient specimens (cases) from 158 patients …

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