Kangjie Wang

Prediction of persistent type II endoleak after endovascular aortic repair using machine learning based on preoperative clinical data and radiomic

Jinqing Mo, Qi Liu, Kangjie Wang, Lin Huang et autres

BACKGROUND: Persistent type II endoleak (T2EL) is associated with adverse outcomes following Endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms. PURPOSE: The purpose of this study was to explore the feasibility of predicting persistent T2ELs after EVAR using preoperative clinical data and …

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Col1a2-As1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells in Lower Extremity Arteriosclerosis Obliterans Through Targeting Igf2bp1-Atf4 Axis

Yao Chen, Kangjie Wang, Yaqing Zhan, Lin Huang et autres

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Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation

Qinghui Kan, Zhanli Peng, Kangjie Wang, Deng Tang et autres

Lower limb arterial occlusive disease is treated with intraluminal devices, such as paclitaxel (PTX)-coated balloons (PCBs); however, post-procedural restenosis remains a significant challenge. NLRP3 activation is known to play a significant role in atherosclerosis, but its involvement in restenosis following PCB intervention …

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Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis

Zhanli Peng, Qinghui Kan, Kangjie Wang, Deng Tang et autres

BACKGROUND: Ruptured atherosclerotic plaques often precipitate severe ischemic events, such as stroke and myocardial infarction. Unraveling the intricate molecular mechanisms governing vascular smooth muscle cell (VSMC) behavior in plaque stabilization remains a formidable challenge. METHODS: In this study, we leveraged single-cell and …

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Revealing PPP1R12B and COL1A1 as piRNA pathway genes contributing to abdominal aortic aneurysm through integrated analysis and experimental validation

Dong‐Dong Jia, Kangjie Wang, Lin Huang, Zhihao Zhou et autres

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PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome

Kangjie Wang, Zhihao Zhou, Lin Huang, Qinghui Kan et autres

Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential common underlying pathogenesis. Mitochondrial dysfunction has been …

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Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability

Zhanli Peng, Kangjie Wang, Shenming Wang, Ridong Wu et autres

BACKGROUND: Atherosclerosis (AS) is a leading cause of morbidity and mortality in older patients and features progressive formation of plaques in vascular tissues. With the progression of atherosclerosis, plaque rupture may occur and cause stroke, myocardial infarction, etc. Different forms of cell …

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Identification of Necroptosis-Related Gene TRAF5 as Potential Targets of Diagnosing Atherosclerosis and Assessing Its Stability

Zhanli Peng, Kangjie Wang, Shenming Wang, Ridong Wu et autres

Abstract Background Atherosclerosis (AS) is a leading cause of morbidity and mortality in older patients and features progressive formation of plaques in vascular tissues. With the progression of atherosclerosis, plaque rupture may occur and cause stroke, myocardial infarction, etc. Different forms of …

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Differential expression pattern, bioinformatics analysis, and validation of circRNA and mRNA in patients with arteriosclerosis

Yunyun Liu, Kangjie Wang, Guanhua Li, Zhibo Chen

Background: Lower limb arteriosclerosis obliterans (ASO) is the formation of atherosclerotic plaques in lower limb arteries, leading to vascular stenosis and occlusion, and is a major factor leading to lower limb amputation. The ASO seriously endangers the physical and mental health of …

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The Long Non-coding RNA AC148477.2 Is a Novel Therapeutic Target Associated With Vascular Smooth Muscle Cells Proliferation of Femoral Atherosclerosis

Kangjie Wang, Yanchen Ye, Lin Huang, Ridong Wu et autres

Arteriosclerosis obliterans (ASO) is a limb manifestation of large vessel atherosclerosis. Phenotype switching of vascular smooth muscle cells (VSMCs) occurs in the course of the pathological process. The underlying mechanism of SMCs proliferation remains unclear. Several studies have demonstrated that the dysregulation …

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Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis

Tucheng Huang, Kangjie Wang, Yuewei Li, Yanchen Ye et autres

Atheroclerosis refers to a chronic inflammatory disease featured by the accumulation of fibrofatty lesions in the intima of arteries. Cardiovasular events associated with atherosclerosis remain the major causes of mortality worldwide. Recent studies have indicated that ferroptosis, a novel programmed cell death, …

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Early Renal-Replacement Therapy May Reduce the All-Cause Mortality of Severe COVID-19: An Observational Cohort Study

Jing Qian, Mengjing Wang, Huaizhou You, Jianfeng Luo et autres

INTRODUCTION: The efficacy of renal-replacement treatment (RRT) remains to be validated in COVID-19. In this retrospective cohort study, we aimed to assess the efficacy of early initiation of RRT in intensive care unit (ICU) adults with severe COVID-19. METHODS: Fifty-eight adult patients …

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